Rapid Functional Divergence of a Newly Evolved Polyubiquitin Gene in Drosophila and Its Role in the Trade-off between Male Fecundity and Lifespan

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	Rapid Functional Divergence of a Newly Evolved Polyubiquitin Gene in Drosophila and Its Role in the Trade-off between Male Fecundity and Lifespan
	Zhan ZB 1,2; Ding Y 1,2; Zhao RP 1; Zhang Y 1; Yu HJ 1,3; Zhou Q 1; Yang S 1; Xiang H1; Wang W1; xiangh@mail.kiz.ac.cn ; wwang@mail.kiz.ac.cn
	2012
发表期刊	MOLECULAR BIOLOGY AND EVOLUTION
卷号	29 期号:5 页码:1407-1416
合作性质	其它
摘要	The cost of reproduction is a pivotal trade-off with various biological processes during the evolution of organisms. However, the genes and molecular mechanisms underlying the evolution of balancing reproductive capacity and its cost are still largely unknown. Here, we present a comprehensive study on the evolution, expression, and biological functions of a newly evolved pair of X-linked polyubiquitin tandemly duplicated genes, CG32744 and CG11700, of which the duplication event occurred in Drosophila melanogaster lineage after the split from D. simulans clade. We found that CG32744 retains conserved polyubiquitin-coding sequences across Drosophila species and is ubiquitously expressed, whereas CG11700 has accumulated numerous amino acid changes and shows a male-specific expression pattern. Null mutants of CG11700 have a higher male fecundity but shorter lifespan, whereas its overexpression decreases male fecundity. In contrast, the null mutants of the peptide-conserved CG32744 do not exhibit such phenotypes. These results suggest that CG11700 might have experienced neofunctionalization and evolved important functions in the trade-off between male fecundity and lifespan and that CG32744 likely has retained the ancestral function
关键词	Duplicated Polyubiquitin Gene Cg11700 Functional Divergence Reproductive Cost
资助者	This work was supported by an NSFC key grant (No. 30930056) to W.W., State Key Laboratory of Genetic Resources and Evo- lution Project (GREKF08-02), and a grant of The National Natural Science Foundation of China (NSFC) (30871342) to H.Y. ; This work was supported by an NSFC key grant (No. 30930056) to W.W., State Key Laboratory of Genetic Resources and Evo- lution Project (GREKF08-02), and a grant of The National Natural Science Foundation of China (NSFC) (30871342) to H.Y. ; This work was supported by an NSFC key grant (No. 30930056) to W.W., State Key Laboratory of Genetic Resources and Evo- lution Project (GREKF08-02), and a grant of The National Natural Science Foundation of China (NSFC) (30871342) to H.Y. ; This work was supported by an NSFC key grant (No. 30930056) to W.W., State Key Laboratory of Genetic Resources and Evo- lution Project (GREKF08-02), and a grant of The National Natural Science Foundation of China (NSFC) (30871342) to H.Y.
收录类别	SCI
语种	英语
资助者	This work was supported by an NSFC key grant (No. 30930056) to W.W., State Key Laboratory of Genetic Resources and Evo- lution Project (GREKF08-02), and a grant of The National Natural Science Foundation of China (NSFC) (30871342) to H.Y. ; This work was supported by an NSFC key grant (No. 30930056) to W.W., State Key Laboratory of Genetic Resources and Evo- lution Project (GREKF08-02), and a grant of The National Natural Science Foundation of China (NSFC) (30871342) to H.Y. ; This work was supported by an NSFC key grant (No. 30930056) to W.W., State Key Laboratory of Genetic Resources and Evo- lution Project (GREKF08-02), and a grant of The National Natural Science Foundation of China (NSFC) (30871342) to H.Y. ; This work was supported by an NSFC key grant (No. 30930056) to W.W., State Key Laboratory of Genetic Resources and Evo- lution Project (GREKF08-02), and a grant of The National Natural Science Foundation of China (NSFC) (30871342) to H.Y.
WOS记录号	WOS:000303603300010
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/6958
专题	基因起源组遗传资源与进化国家重点实验室
通讯作者	xiangh@mail.kiz.ac.cn; wwang@mail.kiz.ac.cn
作者单位	1.CAS-Max Planck Junior Research Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.Graduate University of the Chinese Academy Sciences, Beijing, China 3.Laboratory for Conservation and Utilization of Bio-resources and Human Genetics Center of Yunnan University, Kunming, China
推荐引用方式 GB/T 7714	Zhan ZB,Ding Y,Zhao RP,et al. Rapid Functional Divergence of a Newly Evolved Polyubiquitin Gene in Drosophila and Its Role in the Trade-off between Male Fecundity and Lifespan[J]. MOLECULAR BIOLOGY AND EVOLUTION,2012,29(5):1407-1416.
APA	Zhan ZB.,Ding Y.,Zhao RP.,Zhang Y.,Yu HJ.,...&wwang@mail.kiz.ac.cn.(2012).Rapid Functional Divergence of a Newly Evolved Polyubiquitin Gene in Drosophila and Its Role in the Trade-off between Male Fecundity and Lifespan.MOLECULAR BIOLOGY AND EVOLUTION,29(5),1407-1416.
MLA	Zhan ZB,et al."Rapid Functional Divergence of a Newly Evolved Polyubiquitin Gene in Drosophila and Its Role in the Trade-off between Male Fecundity and Lifespan".MOLECULAR BIOLOGY AND EVOLUTION 29.5(2012):1407-1416.

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