Dynamics and functions of CD4(+)CD25(high) regulatory T lymphocytes in Chinese rhesus macaques during the early stage of infection with SIVmac239

	Dynamics and functions of CD4(+)CD25(high) regulatory T lymphocytes in Chinese rhesus macaques during the early stage of infection with SIVmac239
	Li SY 1,2; Xia HJ 1,2; Dai ZX 1,2; Zhang GH 1; Fan B 1,3; Li MH 1; Wang RR 1; Zheng YT*1; zhengyt@mail.kiz.ac.cn
	2012
发表期刊	ARCHIVES OF VIROLOGY
卷号	157 期号:5 页码:961-967
合作性质	其它
摘要	CD4(+)CD25(high) regulatory T cells (Treg), which are a specialized subset of T cells, play an important role in the prevention of autoimmune diseases, maintenance of immune system homeostasis and tolerance to self-antigens. Chinese rhesus macaques (CRMs) are widely used in preclinical research on potential therapeutic drugs, vaccines and mechanisms of human diseases. However, the basic immunological characterization of Treg cells of CRMs has not been well established. To characterize Treg cells, peripheral blood of 43 adult CRMs was analyzed for CD4+ T lymphocytes by flow cytometry. It was found that Treg cells ranged from 1.52% to 11.1% of CD4+ T cells, and the average value was 5.7%. With our SIV-infected CRM model, through further studies, it was found that Treg cells in peripheral blood increased both in relative and absolute quantities. Moreover, Treg cells maintained their functions by suppressing Th1 cytokine secretion of their target cells. The results show that Treg cells might render cellular immunity against SIV viruses dysfunctional during the early stage after infection.
资助者	This work was supported in part by grants from the National Basic Research Program of China (2012CBA01305, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601, 81172876), the Knowledge Inno- vation Program of CAS (KSCX1-YW-R-15, KSCX2-YW-R-185, KSCX2-EW-R-13), the Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2012ZX10001-006, 2012ZX10001-007) and ‘‘Western Light’’ Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2012CBA01305, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601, 81172876), the Knowledge Inno- vation Program of CAS (KSCX1-YW-R-15, KSCX2-YW-R-185, KSCX2-EW-R-13), the Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2012ZX10001-006, 2012ZX10001-007) and ‘‘Western Light’’ Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2012CBA01305, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601, 81172876), the Knowledge Inno- vation Program of CAS (KSCX1-YW-R-15, KSCX2-YW-R-185, KSCX2-EW-R-13), the Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2012ZX10001-006, 2012ZX10001-007) and ‘‘Western Light’’ Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2012CBA01305, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601, 81172876), the Knowledge Inno- vation Program of CAS (KSCX1-YW-R-15, KSCX2-YW-R-185, KSCX2-EW-R-13), the Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2012ZX10001-006, 2012ZX10001-007) and ‘‘Western Light’’ Projects of CAS.
收录类别	SCI
语种	英语
资助者	This work was supported in part by grants from the National Basic Research Program of China (2012CBA01305, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601, 81172876), the Knowledge Inno- vation Program of CAS (KSCX1-YW-R-15, KSCX2-YW-R-185, KSCX2-EW-R-13), the Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2012ZX10001-006, 2012ZX10001-007) and ‘‘Western Light’’ Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2012CBA01305, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601, 81172876), the Knowledge Inno- vation Program of CAS (KSCX1-YW-R-15, KSCX2-YW-R-185, KSCX2-EW-R-13), the Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2012ZX10001-006, 2012ZX10001-007) and ‘‘Western Light’’ Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2012CBA01305, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601, 81172876), the Knowledge Inno- vation Program of CAS (KSCX1-YW-R-15, KSCX2-YW-R-185, KSCX2-EW-R-13), the Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2012ZX10001-006, 2012ZX10001-007) and ‘‘Western Light’’ Projects of CAS. ; This work was supported in part by grants from the National Basic Research Program of China (2012CBA01305, 2009CB522300), the National Natural Science Foundation of China (30872317, 30800113, U0832601, 81172876), the Knowledge Inno- vation Program of CAS (KSCX1-YW-R-15, KSCX2-YW-R-185, KSCX2-EW-R-13), the Key Scientific and Technological Program of China (2008ZX10001-002, 2008ZX10001-015, 2008ZX10005-005, 2009ZX09501-029, 2012ZX10001-006, 2012ZX10001-007) and ‘‘Western Light’’ Projects of CAS.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7015
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	zhengyt@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100039, China 3.College of Life Science, Xuzhou Normal University, Xuzhou 221116, Jiangsu, China
推荐引用方式 GB/T 7714	Li SY,Xia HJ,Dai ZX,et al. Dynamics and functions of CD4(+)CD25(high) regulatory T lymphocytes in Chinese rhesus macaques during the early stage of infection with SIVmac239[J]. ARCHIVES OF VIROLOGY,2012,157(5):961-967.
APA	Li SY.,Xia HJ.,Dai ZX.,Zhang GH.,Fan B.,...&zhengyt@mail.kiz.ac.cn.(2012).Dynamics and functions of CD4(+)CD25(high) regulatory T lymphocytes in Chinese rhesus macaques during the early stage of infection with SIVmac239.ARCHIVES OF VIROLOGY,157(5),961-967.
MLA	Li SY,et al."Dynamics and functions of CD4(+)CD25(high) regulatory T lymphocytes in Chinese rhesus macaques during the early stage of infection with SIVmac239".ARCHIVES OF VIROLOGY 157.5(2012):961-967.

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