WWP1: a versatile ubiquitin E3 ligase in signaling and diseases

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	WWP1: a versatile ubiquitin E3 ligase in signaling and diseases
	Zhi X 1,2; Chen CS*1; chenc@mail.kiz.ac.cn
	2012
发表期刊	CELLULAR AND MOLECULAR LIFE SCIENCES
卷号	69 期号:9 页码:1425-1434
合作性质	其它
摘要	WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) is a multifunction protein containing an N-terminal C2 domain, four tandem WW domains for substrate binding, and a C-terminal catalytic HECT domain for ubiquitin transferring. WWP1 has been suggested to function as the E3 ligase for several PY motif-containing proteins, such as Smad2, KLF5, p63, ErbB4/HER4, RUNX2, JunB, RNF11, SPG20, and Gag, as well as several non-PY motif containing proteins, such as TβR1, Smad4, KLF2, and EPS15. WWP1 regulates a variety of cellular biological processes including protein trafficking and degradation, signaling, transcription, and viral budding. WWP1 has been implicated in several diseases, such as cancers, infectious diseases, neurological diseases, and aging. In this review article, we extensively summarize the current knowledge of WWP1 with special emphasis on the roles and action of mechanism of WWP1 in signaling and human diseases.
关键词	Wwp1 Ww Domain Py Motif Ubiquitin E3 Ligase Ubiquitination Cancer
资助者	This work was supported in part by grants from National Nature Science Foundation of China (81072162 and 81120108019) and a grant from Yunnan Province High-Profile Sci- entists Program ( 2010CI114). ; This work was supported in part by grants from National Nature Science Foundation of China (81072162 and 81120108019) and a grant from Yunnan Province High-Profile Sci- entists Program ( 2010CI114). ; This work was supported in part by grants from National Nature Science Foundation of China (81072162 and 81120108019) and a grant from Yunnan Province High-Profile Sci- entists Program ( 2010CI114). ; This work was supported in part by grants from National Nature Science Foundation of China (81072162 and 81120108019) and a grant from Yunnan Province High-Profile Sci- entists Program ( 2010CI114).
收录类别	SCI
语种	英语
资助者	This work was supported in part by grants from National Nature Science Foundation of China (81072162 and 81120108019) and a grant from Yunnan Province High-Profile Sci- entists Program ( 2010CI114). ; This work was supported in part by grants from National Nature Science Foundation of China (81072162 and 81120108019) and a grant from Yunnan Province High-Profile Sci- entists Program ( 2010CI114). ; This work was supported in part by grants from National Nature Science Foundation of China (81072162 and 81120108019) and a grant from Yunnan Province High-Profile Sci- entists Program ( 2010CI114). ; This work was supported in part by grants from National Nature Science Foundation of China (81072162 and 81120108019) and a grant from Yunnan Province High-Profile Sci- entists Program ( 2010CI114).
WOS记录号	WOS:000303408800003
引用统计	被引频次：49[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7016
专题	科研部门_肿瘤生物学（陈策实）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	chenc@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zool 2.The Center for Cell Biology and Cancer Research, Albany Medical College, 47, New Scotland Ave., Albany, NY 12208, USA
推荐引用方式 GB/T 7714	Zhi X,Chen CS*,chenc@mail.kiz.ac.cn. WWP1: a versatile ubiquitin E3 ligase in signaling and diseases[J]. CELLULAR AND MOLECULAR LIFE SCIENCES,2012,69(9):1425-1434.
APA	Zhi X,Chen CS*,&chenc@mail.kiz.ac.cn.(2012).WWP1: a versatile ubiquitin E3 ligase in signaling and diseases.CELLULAR AND MOLECULAR LIFE SCIENCES,69(9),1425-1434.
MLA	Zhi X,et al."WWP1: a versatile ubiquitin E3 ligase in signaling and diseases".CELLULAR AND MOLECULAR LIFE SCIENCES 69.9(2012):1425-1434.

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