Deficits in Water Maze Performance and Oxidative Stress in the Hippocampus and Striatum Induced by Extremely Low Frequency Magnetic Field Exposure

KIZ OpenIR > 认知障碍病理学

	Deficits in Water Maze Performance and Oxidative Stress in the Hippocampus and Striatum Induced by Extremely Low Frequency Magnetic Field Exposure
	Cui YH 1; Ge ZQ 1; Rizak JD 2; Zhai C 1; Zhou Z 1; Gong SJ 1; Che Y*1; cheyiwenshan@sina.com
	2012
发表期刊	PLOS ONE
卷号	7 期号:5 页码:e32196
合作性质	其它
摘要	The exposures to extremely low frequency magnetic field (ELF-MF) in our environment have dramatically increased. Epidemiological studies suggest that there is a possible association between ELF-MF exposure and increased risks of cardiovascular disease, cancers and neurodegenerative disorders. Animal studies show that ELF-MF exposure may interfere with the activity of brain cells, generate behavioral and cognitive disturbances, and produce deficits in attention, perception and spatial learning. Although, many research efforts have been focused on the interaction between ELF-MF exposure and the central nervous system, the mechanism of interaction is still unknown. In this study, we examined the effects of ELF-MF exposure on learning in mice using two water maze tasks and on some parameters indicative of oxidative stress in the hippocampus and striatum. We found that ELF-MF exposure (1 mT, 50 Hz) induced serious oxidative stress in the hippocampus and striatum and impaired hippocampal-dependent spatial learning and striatum-dependent habit learning. This study provides evidence for the association between the impairment of learning and the oxidative stress in hippocampus and striatum induced by ELF-MF exposure.
资助者	This work was supported by National Basic Research Program of China, Chinese National Science Foundation (31172089) ; This work was supported by National Basic Research Program of China, Chinese National Science Foundation (31172089) ; This work was supported by National Basic Research Program of China, Chinese National Science Foundation (31172089) ; This work was supported by National Basic Research Program of China, Chinese National Science Foundation (31172089)
收录类别	SCI
语种	英语
资助者	This work was supported by National Basic Research Program of China, Chinese National Science Foundation (31172089) ; This work was supported by National Basic Research Program of China, Chinese National Science Foundation (31172089) ; This work was supported by National Basic Research Program of China, Chinese National Science Foundation (31172089) ; This work was supported by National Basic Research Program of China, Chinese National Science Foundation (31172089)
WOS记录号	WOS:000305343400001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7048
专题	认知障碍病理学科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	cheyiwenshan@sina.com
作者单位	1.Medical College of Soochow University, Suzhou, People’s Republic of China 2.Laboratory of Primate Neuroscience Research, Key Laboratory of Animal Models, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, People’s Republic of China
推荐引用方式 GB/T 7714	Cui YH,Ge ZQ,Rizak JD,et al. Deficits in Water Maze Performance and Oxidative Stress in the Hippocampus and Striatum Induced by Extremely Low Frequency Magnetic Field Exposure[J]. PLOS ONE,2012,7(5):e32196.
APA	Cui YH.,Ge ZQ.,Rizak JD.,Zhai C.,Zhou Z.,...&cheyiwenshan@sina.com.(2012).Deficits in Water Maze Performance and Oxidative Stress in the Hippocampus and Striatum Induced by Extremely Low Frequency Magnetic Field Exposure.PLOS ONE,7(5),e32196.
MLA	Cui YH,et al."Deficits in Water Maze Performance and Oxidative Stress in the Hippocampus and Striatum Induced by Extremely Low Frequency Magnetic Field Exposure".PLOS ONE 7.5(2012):e32196.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2012090708.pdf（967KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文