Exposure to morphine affects the expression of endocannabinoid receptors and immune functions

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	Exposure to morphine affects the expression of endocannabinoid receptors and immune functions
	Zhang QY 1,2; Zhang M 1,2; Cao Y*1; caoy@mail.kiz.ac.cn
	2012
发表期刊	JOURNAL OF NEUROIMMUNOLOGY
卷号	247 期号:1-2 页码:52-58
合作性质	其它
摘要	Compared with control rats, rats under morphine exposure exhibited cannabinoid receptor 2 (CB2-R) upregulation in the spleen and periphery blood mononuclear cells (PBMCs). IgG and IgM values in the plasma were also altered. In morphine abusers, cannabinoid receptors were upregulated in the PBMCs, and the expression of IL-4 mRNA in the PBMCs as well as the IgG and IgM values in the plasma were higher compared with those in healthy people. The expression of cannabinoid receptor 1 and CB2-R in culture cells was directly affected by morphine treatment. These findings indicate that the alteration in cannabinoid receptor expression could be disturbed by morphine exposure, and it may be involved in abnormal immune function.
关键词	Morphine Abuse Cannabinoid Receptor Opioid Receptor Immune Cells Immune Function
资助者	This work was supported by the Chinese Academy of Sciences (KSCX2-YW-R- 092) and Key Laboratory of Animal Models and Human Disease Mecha- nism of CAS and Yunnan Province. ; This work was supported by the Chinese Academy of Sciences (KSCX2-YW-R- 092) and Key Laboratory of Animal Models and Human Disease Mecha- nism of CAS and Yunnan Province. ; This work was supported by the Chinese Academy of Sciences (KSCX2-YW-R- 092) and Key Laboratory of Animal Models and Human Disease Mecha- nism of CAS and Yunnan Province. ; This work was supported by the Chinese Academy of Sciences (KSCX2-YW-R- 092) and Key Laboratory of Animal Models and Human Disease Mecha- nism of CAS and Yunnan Province.
收录类别	SCI
语种	英语
资助者	This work was supported by the Chinese Academy of Sciences (KSCX2-YW-R- 092) and Key Laboratory of Animal Models and Human Disease Mecha- nism of CAS and Yunnan Province. ; This work was supported by the Chinese Academy of Sciences (KSCX2-YW-R- 092) and Key Laboratory of Animal Models and Human Disease Mecha- nism of CAS and Yunnan Province. ; This work was supported by the Chinese Academy of Sciences (KSCX2-YW-R- 092) and Key Laboratory of Animal Models and Human Disease Mecha- nism of CAS and Yunnan Province. ; This work was supported by the Chinese Academy of Sciences (KSCX2-YW-R- 092) and Key Laboratory of Animal Models and Human Disease Mecha- nism of CAS and Yunnan Province.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7055
专题	分子病理学科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	caoy@mail.kiz.ac.cn
作者单位	1.Laboratory of Molecular and Experimental Pathology, Key Laboratory of Animal Models and Human Disease Mechanisms of CAS and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People's Republic of China 2.Graduate University of the Chinese Academy of Sciences, Beijing, People's Republic of China
推荐引用方式 GB/T 7714	Zhang QY,Zhang M,Cao Y*,et al. Exposure to morphine affects the expression of endocannabinoid receptors and immune functions[J]. JOURNAL OF NEUROIMMUNOLOGY,2012,247(1-2):52-58.
APA	Zhang QY,Zhang M,Cao Y*,&caoy@mail.kiz.ac.cn.(2012).Exposure to morphine affects the expression of endocannabinoid receptors and immune functions.JOURNAL OF NEUROIMMUNOLOGY,247(1-2),52-58.
MLA	Zhang QY,et al."Exposure to morphine affects the expression of endocannabinoid receptors and immune functions".JOURNAL OF NEUROIMMUNOLOGY 247.1-2(2012):52-58.

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