The genetic variation of CCR5, CXCR4 and SDF-1 in three Chinese ethnic populations

	The genetic variation of CCR5, CXCR4 and SDF-1 in three Chinese ethnic populations
	Liu YY 1; Liu FL 2; He YQ 3; Li LM 1; Li SL 1; Zheng YT 2; Wang HY1; Gong XH1; wanghy@fudan.edu.cn ; gongxh@fudan.edu.cn
	2012
发表期刊	INFECTION GENETICS AND EVOLUTION
卷号	12 期号:5 页码:1072-1078
摘要	The chemokine receptors and ligand CCR5. CXCR4 and SDF-1 play important roles in the entry of HIV-1 into host cells. Genetic polymorphisms such as CCR5-Delta 32 and SDF-1 3'A have been reported to be associated with HIV-1 susceptibility and the progression of AIDS. Considering the remarkable difference in CCR5-Delta 32 allele frequency among worldwide populations, we aimed to survey the genetic variations in CCR5, CXCR4 and SDF-1 in different Chinese populations. The open reading frames and regulatory regions of CCR5, CXCR4 and SDF-1 were sequenced in 141 Chinese individuals from three ethnic groups: Han, Mongol and Uyghur. Ninety-six variants were identified, 41 of which were newly identified (NI) in Chinese populations. A novel non-synonymous variant c.459 C>T (Trp153Cys) within CCR5 was identified in one Han individual. Of NI variants, 11 were common polymorphisms with a minor allele frequency (MAF) >5%. The polymorphism CCR5-Delta 32 was found in three Uyghur individuals but was absent in Han and Mongol groups. The linkage disequilibrium (LD) analysis of CCR5 and SDF-1 and frequency of CCR5 haplotypes showed considerable divergence among three ethnic groups. Our results show the great genetic heterogeneity within CCR5, CXCR4 and SDF-1 in Chinese ethnic populations.
关键词	Hiv Ccr5 Cxcr4 Sdf-1 Polymorphism
资助者	We sincerely thank all the staff who participated in this study. Supported by National Basic Research Program of China (2009CB522007), National Natural Science Foundation of China (30900404, U0832601), National Science Fund for Distinguished Young Scholars (81025003) and Doctoral Fund of Ministry of Education of China (200802461043). ; We sincerely thank all the staff who participated in this study. Supported by National Basic Research Program of China (2009CB522007), National Natural Science Foundation of China (30900404, U0832601), National Science Fund for Distinguished Young Scholars (81025003) and Doctoral Fund of Ministry of Education of China (200802461043). ; We sincerely thank all the staff who participated in this study. Supported by National Basic Research Program of China (2009CB522007), National Natural Science Foundation of China (30900404, U0832601), National Science Fund for Distinguished Young Scholars (81025003) and Doctoral Fund of Ministry of Education of China (200802461043). ; We sincerely thank all the staff who participated in this study. Supported by National Basic Research Program of China (2009CB522007), National Natural Science Foundation of China (30900404, U0832601), National Science Fund for Distinguished Young Scholars (81025003) and Doctoral Fund of Ministry of Education of China (200802461043).
收录类别	SCI
语种	英语
资助者	We sincerely thank all the staff who participated in this study. Supported by National Basic Research Program of China (2009CB522007), National Natural Science Foundation of China (30900404, U0832601), National Science Fund for Distinguished Young Scholars (81025003) and Doctoral Fund of Ministry of Education of China (200802461043). ; We sincerely thank all the staff who participated in this study. Supported by National Basic Research Program of China (2009CB522007), National Natural Science Foundation of China (30900404, U0832601), National Science Fund for Distinguished Young Scholars (81025003) and Doctoral Fund of Ministry of Education of China (200802461043). ; We sincerely thank all the staff who participated in this study. Supported by National Basic Research Program of China (2009CB522007), National Natural Science Foundation of China (30900404, U0832601), National Science Fund for Distinguished Young Scholars (81025003) and Doctoral Fund of Ministry of Education of China (200802461043). ; We sincerely thank all the staff who participated in this study. Supported by National Basic Research Program of China (2009CB522007), National Natural Science Foundation of China (30900404, U0832601), National Science Fund for Distinguished Young Scholars (81025003) and Doctoral Fund of Ministry of Education of China (200802461043).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7059
专题	科研部门_分子免疫药理学（郑永唐）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	wanghy@fudan.edu.cn; gongxh@fudan.edu.cn
作者单位	1.The State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 3.Institute of Biochemistry and Molecular Biology, Shanxi Normal University School of Life Sciences, Xian, China
推荐引用方式 GB/T 7714	Liu YY,Liu FL,He YQ,et al. The genetic variation of CCR5, CXCR4 and SDF-1 in three Chinese ethnic populations[J]. INFECTION GENETICS AND EVOLUTION,2012,12(5):1072-1078.
APA	Liu YY.,Liu FL.,He YQ.,Li LM.,Li SL.,...&gongxh@fudan.edu.cn.(2012).The genetic variation of CCR5, CXCR4 and SDF-1 in three Chinese ethnic populations.INFECTION GENETICS AND EVOLUTION,12(5),1072-1078.
MLA	Liu YY,et al."The genetic variation of CCR5, CXCR4 and SDF-1 in three Chinese ethnic populations".INFECTION GENETICS AND EVOLUTION 12.5(2012):1072-1078.

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