Mycobacterium smegmatis genomic characteristics associated with its saprophyte lifestyle

KIZ OpenIR > 基因起源组（王文）

	Mycobacterium smegmatis genomic characteristics associated with its saprophyte lifestyle
	Long QX 1; Zhou Q 2,3; Ji L 1; Wu J 1; Wang W 2; Xie JP*1; georgex@swu.edu.cn
	2012
发表期刊	JOURNAL OF CELLULAR BIOCHEMISTRY
卷号	113 期号:10 页码:3051-3055
合作性质	其它
摘要	Tuberculosis (TB) remains a great threat to global public health. The high biosafety level III required to tackle its causative agent Mycobacterium tuberculosis seriously hinders the exploration of its biology and new countermeasures. M. smegmatis is a widely recognized good surrogate of M. tuberculosis, largely due to their conserved transcriptional machinery, sigma factors, and two-component systems. However, their distinct lifestyles often confound the explanation of the results. M. tuberculosis leads both parasitic and free life, while M. smegmatis is largely saprophyte. To make full advantage of this model, it is helpful to discover the genome features associated with M. smegmatis unique niches, such as its saprophytic life, high salt tolerance, and relative short generation time. We employed the gene ontology enrichment analysis to characterize the unique lifestyle of M. smegmatis. Gene ontology enrichment analysis provided 12 terms; most are relevant to the special lifestyle of M. smegmatis, especially the saprophytic niche, high salt tolerance adaptation, and short generation time. In-depth functional characterization of these genes will shed new lights on the genetic basis of M. smegmatis saprophytic life and hasten the understanding of the unique biology of M. tuberculosis. J. Cell. Biochem. 113: 30513055, 2012. (c) 2012 Wiley Periodicals, Inc.
资助者	The National key infectious disease project; Grant numbers: 2008ZX10003-006, 2012ZX10003-003; Grant sponsor: Excellent PhD thesis fellowship of southwest university; Grant number: ky2011003; Grant sponsor: New century excellent talents in Universities; Grant number: NCET-11-; Grant sponsor: The National Natural Science Foundation; Grant number: 81071316; Grant sponsor: The Fundamental Research Funds for the Central Universities; Grantnumber:XDJK2009A003;Grantsponsor:NaturalScienceFoundationProjectofCQCSTC;Grantnumber:CSTC, 2010BB5002. ; The National key infectious disease project; Grant numbers: 2008ZX10003-006, 2012ZX10003-003; Grant sponsor: Excellent PhD thesis fellowship of southwest university; Grant number: ky2011003; Grant sponsor: New century excellent talents in Universities; Grant number: NCET-11-; Grant sponsor: The National Natural Science Foundation; Grant number: 81071316; Grant sponsor: The Fundamental Research Funds for the Central Universities; Grantnumber:XDJK2009A003;Grantsponsor:NaturalScienceFoundationProjectofCQCSTC;Grantnumber:CSTC, 2010BB5002. ; The National key infectious disease project; Grant numbers: 2008ZX10003-006, 2012ZX10003-003; Grant sponsor: Excellent PhD thesis fellowship of southwest university; Grant number: ky2011003; Grant sponsor: New century excellent talents in Universities; Grant number: NCET-11-; Grant sponsor: The National Natural Science Foundation; Grant number: 81071316; Grant sponsor: The Fundamental Research Funds for the Central Universities; Grantnumber:XDJK2009A003;Grantsponsor:NaturalScienceFoundationProjectofCQCSTC;Grantnumber:CSTC, 2010BB5002. ; The National key infectious disease project; Grant numbers: 2008ZX10003-006, 2012ZX10003-003; Grant sponsor: Excellent PhD thesis fellowship of southwest university; Grant number: ky2011003; Grant sponsor: New century excellent talents in Universities; Grant number: NCET-11-; Grant sponsor: The National Natural Science Foundation; Grant number: 81071316; Grant sponsor: The Fundamental Research Funds for the Central Universities; Grantnumber:XDJK2009A003;Grantsponsor:NaturalScienceFoundationProjectofCQCSTC;Grantnumber:CSTC, 2010BB5002.
收录类别	SCI
语种	英语
资助者	The National key infectious disease project; Grant numbers: 2008ZX10003-006, 2012ZX10003-003; Grant sponsor: Excellent PhD thesis fellowship of southwest university; Grant number: ky2011003; Grant sponsor: New century excellent talents in Universities; Grant number: NCET-11-; Grant sponsor: The National Natural Science Foundation; Grant number: 81071316; Grant sponsor: The Fundamental Research Funds for the Central Universities; Grantnumber:XDJK2009A003;Grantsponsor:NaturalScienceFoundationProjectofCQCSTC;Grantnumber:CSTC, 2010BB5002. ; The National key infectious disease project; Grant numbers: 2008ZX10003-006, 2012ZX10003-003; Grant sponsor: Excellent PhD thesis fellowship of southwest university; Grant number: ky2011003; Grant sponsor: New century excellent talents in Universities; Grant number: NCET-11-; Grant sponsor: The National Natural Science Foundation; Grant number: 81071316; Grant sponsor: The Fundamental Research Funds for the Central Universities; Grantnumber:XDJK2009A003;Grantsponsor:NaturalScienceFoundationProjectofCQCSTC;Grantnumber:CSTC, 2010BB5002. ; The National key infectious disease project; Grant numbers: 2008ZX10003-006, 2012ZX10003-003; Grant sponsor: Excellent PhD thesis fellowship of southwest university; Grant number: ky2011003; Grant sponsor: New century excellent talents in Universities; Grant number: NCET-11-; Grant sponsor: The National Natural Science Foundation; Grant number: 81071316; Grant sponsor: The Fundamental Research Funds for the Central Universities; Grantnumber:XDJK2009A003;Grantsponsor:NaturalScienceFoundationProjectofCQCSTC;Grantnumber:CSTC, 2010BB5002. ; The National key infectious disease project; Grant numbers: 2008ZX10003-006, 2012ZX10003-003; Grant sponsor: Excellent PhD thesis fellowship of southwest university; Grant number: ky2011003; Grant sponsor: New century excellent talents in Universities; Grant number: NCET-11-; Grant sponsor: The National Natural Science Foundation; Grant number: 81071316; Grant sponsor: The Fundamental Research Funds for the Central Universities; Grantnumber:XDJK2009A003;Grantsponsor:NaturalScienceFoundationProjectofCQCSTC;Grantnumber:CSTC, 2010BB5002.
WOS记录号	WOS:000307344800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7063
专题	基因起源组（王文）遗传资源与进化国家重点实验室
通讯作者	georgex@swu.edu.cn
作者单位	1.Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing 400715, P. R. China 2.Chinese Academy Science, Kunming Inst Zool, State Key Lab Genet Resources & Evolution, CAS Max Planck Jr Res Grp, Kunming 650223, Yunnan, P. R. China 3.Department of Integrative Biology, Center for Theoretical Evolutionary Genomics, 3060 VLSB, University of California, Berkeley, California 94720
推荐引用方式 GB/T 7714	Long QX,Zhou Q,Ji L,et al. Mycobacterium smegmatis genomic characteristics associated with its saprophyte lifestyle[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2012,113(10):3051-3055.
APA	Long QX.,Zhou Q.,Ji L.,Wu J.,Wang W.,...&georgex@swu.edu.cn.(2012).Mycobacterium smegmatis genomic characteristics associated with its saprophyte lifestyle.JOURNAL OF CELLULAR BIOCHEMISTRY,113(10),3051-3055.
MLA	Long QX,et al."Mycobacterium smegmatis genomic characteristics associated with its saprophyte lifestyle".JOURNAL OF CELLULAR BIOCHEMISTRY 113.10(2012):3051-3055.

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