Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans

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	Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans
	Zhou Q 1,2; Zhu HM 3; Huang QF 3; Zhao L1; Bachtrog D2; Zhang GJ 1,3; Roy SW 4; Vicoso B 2; Xuan ZL 3; Ruan J 2; Zhang Y 1; Zhao RP 1; Ye C 3; Zhang XQ 3; Wang J1; Wang W1; zhutom00@gmail.com ; xuanzl@genomics.org.cn ; wangj@genomics.org.cn ; wwang@mail.kiz.ac.cn ; dbachtrog@berkeley.edu
	2012
发表期刊	BMC GENOMICS
卷号	13 期号:X 页码:e109
合作性质	其它
摘要	Background: Drosophila albomicans is a unique model organism for studying both sex chromosome and B chromosome evolution. A pair of its autosomes comprising roughly 40% of the whole genome has fused to the ancient X and Y chromosomes only about 0.12 million years ago, thereby creating the youngest and most gene-rich neo-sex system reported to date. This species also possesses recently derived B chromosomes that show non-Mendelian inheritance and significantly influence fertility. Methods: We sequenced male flies with B chromosomes at 124.5-fold genome coverage using next-generation sequencing. To characterize neo-Y specific changes and B chromosome sequences, we also sequenced inbred female flies derived from the same strain but without B's at 28.5-fold. Results: We assembled a female genome and placed 53% of the sequence and 85% of the annotated proteins into specific chromosomes, by comparison with the 12 Drosophila genomes. Despite its very recent origin, the non-recombining neo-Y chromosome shows various signs of degeneration, including a significant enrichment of nonfunctional genes compared to the neo-X, and an excess of tandem duplications relative to other chromosomes. We also characterized a B-chromosome linked scaffold that contains an actively transcribed unit and shows sequence similarity to the subcentromeric regions of both the ancient X and the neo-X chromosome. Conclusions: Our results provide novel insights into the very early stages of sex chromosome evolution and B chromosome origination, and suggest an unprecedented connection between the births of these two systems in D. albomicans.
关键词	Drosophila Albomicans Neo-sex Chromosome b Chromosome
资助者	This work was supported by a CAS key grant (KSCX2-YW-N-060), two National Natural Science Foundation of China (NSFC) key grants (No. 30430400 and 30930056), a 973 Program (No. 2007CB815700), a CAS-Max Planck Society Fellowship, and the 100 Talent Program of CAS to W.W; and a National Natural Science Foundation of China (30725008), a Chinese 863 program (2006AA10A121), a Danish Platform for Integrative Biology, the Ole Rømer grant from the Danish Natural Science Research Council, NIH grants (R01GM076007 and R01GM093182) and a Packard Fellowship to D.B.; and the Solexa project (272-07-0196) to J.W. ; This work was supported by a CAS key grant (KSCX2-YW-N-060), two National Natural Science Foundation of China (NSFC) key grants (No. 30430400 and 30930056), a 973 Program (No. 2007CB815700), a CAS-Max Planck Society Fellowship, and the 100 Talent Program of CAS to W.W; and a National Natural Science Foundation of China (30725008), a Chinese 863 program (2006AA10A121), a Danish Platform for Integrative Biology, the Ole Rømer grant from the Danish Natural Science Research Council, NIH grants (R01GM076007 and R01GM093182) and a Packard Fellowship to D.B.; and the Solexa project (272-07-0196) to J.W. ; This work was supported by a CAS key grant (KSCX2-YW-N-060), two National Natural Science Foundation of China (NSFC) key grants (No. 30430400 and 30930056), a 973 Program (No. 2007CB815700), a CAS-Max Planck Society Fellowship, and the 100 Talent Program of CAS to W.W; and a National Natural Science Foundation of China (30725008), a Chinese 863 program (2006AA10A121), a Danish Platform for Integrative Biology, the Ole Rømer grant from the Danish Natural Science Research Council, NIH grants (R01GM076007 and R01GM093182) and a Packard Fellowship to D.B.; and the Solexa project (272-07-0196) to J.W. ; This work was supported by a CAS key grant (KSCX2-YW-N-060), two National Natural Science Foundation of China (NSFC) key grants (No. 30430400 and 30930056), a 973 Program (No. 2007CB815700), a CAS-Max Planck Society Fellowship, and the 100 Talent Program of CAS to W.W; and a National Natural Science Foundation of China (30725008), a Chinese 863 program (2006AA10A121), a Danish Platform for Integrative Biology, the Ole Rømer grant from the Danish Natural Science Research Council, NIH grants (R01GM076007 and R01GM093182) and a Packard Fellowship to D.B.; and the Solexa project (272-07-0196) to J.W.
收录类别	SCI
语种	英语
资助者	This work was supported by a CAS key grant (KSCX2-YW-N-060), two National Natural Science Foundation of China (NSFC) key grants (No. 30430400 and 30930056), a 973 Program (No. 2007CB815700), a CAS-Max Planck Society Fellowship, and the 100 Talent Program of CAS to W.W; and a National Natural Science Foundation of China (30725008), a Chinese 863 program (2006AA10A121), a Danish Platform for Integrative Biology, the Ole Rømer grant from the Danish Natural Science Research Council, NIH grants (R01GM076007 and R01GM093182) and a Packard Fellowship to D.B.; and the Solexa project (272-07-0196) to J.W. ; This work was supported by a CAS key grant (KSCX2-YW-N-060), two National Natural Science Foundation of China (NSFC) key grants (No. 30430400 and 30930056), a 973 Program (No. 2007CB815700), a CAS-Max Planck Society Fellowship, and the 100 Talent Program of CAS to W.W; and a National Natural Science Foundation of China (30725008), a Chinese 863 program (2006AA10A121), a Danish Platform for Integrative Biology, the Ole Rømer grant from the Danish Natural Science Research Council, NIH grants (R01GM076007 and R01GM093182) and a Packard Fellowship to D.B.; and the Solexa project (272-07-0196) to J.W. ; This work was supported by a CAS key grant (KSCX2-YW-N-060), two National Natural Science Foundation of China (NSFC) key grants (No. 30430400 and 30930056), a 973 Program (No. 2007CB815700), a CAS-Max Planck Society Fellowship, and the 100 Talent Program of CAS to W.W; and a National Natural Science Foundation of China (30725008), a Chinese 863 program (2006AA10A121), a Danish Platform for Integrative Biology, the Ole Rømer grant from the Danish Natural Science Research Council, NIH grants (R01GM076007 and R01GM093182) and a Packard Fellowship to D.B.; and the Solexa project (272-07-0196) to J.W. ; This work was supported by a CAS key grant (KSCX2-YW-N-060), two National Natural Science Foundation of China (NSFC) key grants (No. 30430400 and 30930056), a 973 Program (No. 2007CB815700), a CAS-Max Planck Society Fellowship, and the 100 Talent Program of CAS to W.W; and a National Natural Science Foundation of China (30725008), a Chinese 863 program (2006AA10A121), a Danish Platform for Integrative Biology, the Ole Rømer grant from the Danish Natural Science Research Council, NIH grants (R01GM076007 and R01GM093182) and a Packard Fellowship to D.B.; and the Solexa project (272-07-0196) to J.W.
WOS记录号	WOS:000304155800001
引用统计	被引频次：48[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7086
专题	基因起源组遗传资源与进化国家重点实验室
通讯作者	zhutom00@gmail.com; xuanzl@genomics.org.cn; wangj@genomics.org.cn; wwang@mail.kiz.ac.cn; dbachtrog@berkeley.edu
作者单位	1.CAS-Max Planck Junior Research Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Department of Integrative Biology, University of California, Berkeley, CA 94720, USA 3.Beijing Genomics Institute-Shenzhen, Shenzhen 518083, China 4.Department of Biology, Stanford University, Palo Alto, CA 94305, USA
推荐引用方式 GB/T 7714	Zhou Q,Zhu HM,Huang QF,et al. Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans[J]. BMC GENOMICS,2012,13(X):e109.
APA	Zhou Q.,Zhu HM.,Huang QF.,Zhao L.,Bachtrog D.,...&dbachtrog@berkeley.edu.(2012).Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans.BMC GENOMICS,13(X),e109.
MLA	Zhou Q,et al."Deciphering neo-sex and B chromosome evolution by the draft genome of Drosophila albomicans".BMC GENOMICS 13.X(2012):e109.

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