Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia

KIZ OpenIR > 科研部门 > 转化基因组（李明）

	Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia
	Luo XJ1; Huang L 2,3,4; Li M5 ; Gan L6,7; xiongjian_luo@urmc.rochester.edu ; lin_gan@urmc.rochester.edu
	2013
发表期刊	SCHIZOPHRENIA RESEARCH
卷号	143 期号:2-3 页码:390-392
合作性质	其它
摘要	Recent genome-wide association studies have identified many promising schizophrenia candidate genes and demonstrated that common polygenic variation contributes to schizophrenia risk. However, whether these genes represent perturbations to a common but limited set of underlying molecular processes (pathways) that modulate risk to schizophrenia remains elusive, and it is not known whether these genes converge on common biological pathways (networks) or represent different pathways. In addition, the theoretical and genetic mechanisms underlying the strong genetic heterogeneity of schizophrenia remain largely unknown. Using 4 well-defined data sets that contain top schizophrenia susceptibility genes and applying protein-protein interaction (PPI) network analysis, we investigated the interactions among proteins encoded by top schizophrenia susceptibility genes. We found proteins encoded by top schizophrenia susceptibility genes formed a highly significant interconnected network, and, compared with random networks, these PPI networks are statistically highly significant for both direct connectivity and indirect connectivity. We further validated these results using empirical functional data (transcriptome data from a clinical sample). These highly significant findings indicate that top schizophrenia susceptibility genes encode proteins that significantly directly interacted and formed a densely interconnected network, suggesting perturbations of common underlying molecular processes or pathways that modulate risk to schizophrenia. Our findings that schizophrenia susceptibility genes encode a highly interconnected protein network may also provide a novel explanation for the observed genetic heterogeneity of schizophrenia, ie, mutation in any member of this molecular network will lead to same functional consequences that eventually contribute to risk of schizophrenia.
收录类别	SCI
语种	英语
WOS记录号	WOS:000313659000025
引用统计	被引频次：7[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7144
专题	科研部门_转化基因组（李明）遗传资源与进化国家重点实验室科研共享资源
通讯作者	xiongjian_luo@urmc.rochester.edu; lin_gan@urmc.rochester.edu
作者单位	1.Flaum Eye Institute and Department of Ophthalmology, University of Rochester, Rochester, New York, USA 2.Nanchang University, Nanchang, Jiangxi, China 3.Jiangxi Provincial People's Hospital, Nanchang, Jiangxi, China 4.Gannan Medical University, Ganzhou, Jiangxi, China 5.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China 6.Flaum Eye Institute and Department of Ophthalmology, University of Rochester, Rochester, New York, USA 7.College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China
推荐引用方式 GB/T 7714	Luo XJ*,Huang L,Li M,et al. Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2013,143(2-3):390-392.
APA	Luo XJ,Huang L,Li M,Gan L,xiongjian_luo@urmc.rochester.edu,&lin_gan@urmc.rochester.edu.(2013).Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia.SCHIZOPHRENIA RESEARCH,143(2-3),390-392.
MLA	Luo XJ*,et al."Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia".SCHIZOPHRENIA RESEARCH 143.2-3(2013):390-392.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2013022502.pdf（395KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文