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	Genome-wide and Caste-Specific DNA Methylomes of the Ants Camponotus floridanus and Harpegnathos saltator
	Bonasio R1; Li QY3,4; Lian JM3; Mutti NS5; Jin LJ3; Zhao HM3; Zhang P3; Wen P3; Xiang H6; Wang W6; Reinberg D*1; bergers@mail.med.upenn.edu
	2012
发表期刊	CURRENT BIOLOGY
卷号	22期号:19页码:1755-1764;
合作性质	其它
摘要	Background: Ant societies comprise individuals belonging to different castes characterized by specialized morphologies and behaviors. Because ant embryos can follow different developmental trajectories, epigenetic mechanisms must play a role in caste determination. Ants have a full set of DNA methyltransferases and their genomes contain methylcytosine. To determine the relationship between DNA methylation and phenotypic plasticity in ants, we obtained and compared the genome-wide methylonnes of different castes and developmental stages of Camponotus floridanus and Harpegnathos saltator.  Results: In the ant genomes, methylcytosines are found both in symmetric CG dinucleotides (CpG) and non-CpG contexts and are strongly enriched at exons of active genes. Changes in exonic DNA methylation correlate with alternative splicing events such as exon skipping and alternative splice site selection. Several genes exhibit caste-specific and developmental changes in DNA methylation that are conserved between the two species, including genes involved in reproduction, telomere maintenance, and noncoding RNA metabolism. Several loci are methylated and expressed monoallelically, and in some cases, the choice of methylated allele depends on the caste.  Conclusions: These first ant methylomes and their intra- and interspecies comparison reveal an exonic methylation pattern that points to a connection between DNA methylation and splicing. The presence of monoallelic DNA methylation and the methylation of non-CpG sites in all samples suggest roles in genome regulation in these social insects, including the intriguing possibility of parental or caste-specific genomic imprinting.
资助者	This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L.
收录类别	SCI
语种	英语
资助者	This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L. ; This work was funded by a Howard Hughes Medical Institute Collaborative Innovation Award (#2009005) to S.L.B., D.R., and J.L.
WOS记录号	WOS:000309792900018
引用统计	被引频次：199[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7309
专题	基因起源组 遗传资源与进化国家重点实验室
通讯作者	bergers@mail.med.upenn.edu
作者单位	1.Howard Hughes Medical Institute and Department of Biochemistry 2.Center for Health Informatics and Bioinformatics New York University School of Medicine, New York, NY 10016 3.BGI-Shenzhen, Shenzhen 518083, China 4.School of Bioscience and Bioengineering, South China University of Technology, Guangzhou 510006, China 5.School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA 6.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 7.Department of Biology,University of Copenhagen, Universitetsparken 15, København 2100, Denmark 8.The Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen, Universitetsparken 15, København 2100, Denmark 9.University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
推荐引用方式 GB/T 7714	Bonasio R,Li QY,Lian JM,et al. Genome-wide and Caste-Specific DNA Methylomes of the Ants Camponotus floridanus and Harpegnathos saltator[J]. CURRENT BIOLOGY,2012,22(19):1755-1764;.
APA	Bonasio R.,Li QY.,Lian JM.,Mutti NS.,Jin LJ.,...&bergers@mail.med.upenn.edu.(2012).Genome-wide and Caste-Specific DNA Methylomes of the Ants Camponotus floridanus and Harpegnathos saltator.CURRENT BIOLOGY,22(19),1755-1764;.
MLA	Bonasio R,et al."Genome-wide and Caste-Specific DNA Methylomes of the Ants Camponotus floridanus and Harpegnathos saltator".CURRENT BIOLOGY 22.19(2012):1755-1764;.

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2013040814.pdf（635KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文

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