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KIZ OpenIR  > 科研部门  > 分子免疫药理学（郑永唐）
Repositioning HIV‑1 Integrase Inhibitors for Cancer Therapeutics: 1,6-Naphthyridine-7-carboxamide as a Promising Scaffold with Drug-like Properties
Zeng LF1; Wang Y1; Kazemi R2; Xu SL2; Xu ZL1; Sanchez TW2; Yang LM3; Debnath B2; Odde S2; Xie H1; Zheng YT3; Ding J1; Neamati N*2; Long YQ*1; neamati@usc.edu; yqlong@mail.shcnc.ac.cn
2012
发表期刊JOURNAL OF MEDICINAL CHEMISTRY
卷号55期号:22页码:9492-9509
合作性质其它
其他摘要
Among a large number of HIV-1 integrase (IN) inhibitors, the 8-hydroxy-[1,6]naphthyridines (i.e., L-870,810)
were one of the promising class of antiretroviral drugs developed by Merck Laboratories. In spite of its remarkable potency and efficacy, unfortunately upon completion of phase I clinical studies, development of L-870,810 was halted. Because of its desirable pharmacological and pharmaceutical properties we were intrigued to design novel analogues of L-870,810 with goals to (1) improve upon limitations of naphthyridine-7-carboxamides as antiviral agents and (2) to reposition their use as innovative cytotoxic agents for cancer therapeutics. Herein, we report on the design and synthesis of a series of 1,6-naphthyridine-7- carboxamides with various substitutions at the 5- and 8-positions. All the new 5-substituted-8-hydroxy-[1,6]naphthyridines were potent IN inhibitors and the 5-substituted-8-amino-[1,6]naphthyridines were significantly cytotoxic. Further optimization of the
5,8-disubstituted-[1,6]naphthyridines with structural variation on 7-carboxamide delivered novel compounds with significant cytotoxicity in a panel of cancer cell lines and effective inhibition against select oncogenic kinases.
资助者This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.).
收录类别SCI
语种英语
资助者This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.). ; This study was supported in part by the National Natural Science Foundation of China nos. 81021062, 81072527, and 81123004 (Y-Q.L.), 81102483 (L-M. Y); the Key Scientific and Technological Program of China (2012ZX10001-006) (Y.T.Z); and the Sharon and William Cockrell Endowed Cancer Research Fund (N.N.).
文献类型期刊论文
条目标识符http://ir.kiz.ac.cn/handle/152453/7330
专题科研部门_分子免疫药理学（郑永唐）
科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者neamati@usc.edu; yqlong@mail.shcnc.ac.cn
作者单位1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China
2.Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles, California 90089, United States
3.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式
GB/T 7714		 Zeng LF,Wang Y,Kazemi R,等. Repositioning HIV‑1 Integrase Inhibitors for Cancer Therapeutics: 1,6-Naphthyridine-7-carboxamide as a Promising Scaffold with Drug-like Properties[J]. JOURNAL OF MEDICINAL CHEMISTRY,2012,55(22):9492-9509.
APA Zeng LF.,Wang Y.,Kazemi R.,Xu SL.,Xu ZL.,...&yqlong@mail.shcnc.ac.cn.(2012).Repositioning HIV‑1 Integrase Inhibitors for Cancer Therapeutics: 1,6-Naphthyridine-7-carboxamide as a Promising Scaffold with Drug-like Properties.JOURNAL OF MEDICINAL CHEMISTRY,55(22),9492-9509.
MLA Zeng LF,et al."Repositioning HIV‑1 Integrase Inhibitors for Cancer Therapeutics: 1,6-Naphthyridine-7-carboxamide as a Promising Scaffold with Drug-like Properties".JOURNAL OF MEDICINAL CHEMISTRY 55.22(2012):9492-9509.
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