PtdIns(3,4,5)P-3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes

	PtdIns(3,4,5)P-3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes
	Zheng P1,2; Baibakov B 3; Wang XH 2; Dean J3; zhengp@mail.kiz.ac.cn ; jurrien@helix.nih.gov
	2013
发表期刊	JOURNAL OF CELL SCIENCE
卷号	126 期号:3 页码:715-721
合作性质	其它
摘要	Prior to ovulation, mammalian oocytes complete their first meiotic division and arrest at metaphase II. During this marked asymmetric cell division, the meiotic spindle moves dramatically from the center of the oocyte to the cortex to facilitate segregation of half of its chromosomal content into the diminutive first polar body. Recent investigations have documented crucial roles for filamentous actin (F-actin) in meiotic spindle translocation. However, the identity of the upstream regulators responsible for these carefully orchestrated movements has remained elusive. Utilizing fluorescently tagged probes and time-lapse confocal microscopy, we document that phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P-3] is constitutively synthesized with spatial and temporal dynamics similar to that of F-actin and Formin 2 (Fmn2). Blockage of PtdIns(3,4,5) P-3 synthesis by LY294002, a specific inhibitor of phosphoinositide 3-kinase (PI3K), disrupts cytoplasmic F-actin organization and meiotic spindle migration to the cortex. F-actin nucleator Fmn2 and Rho GTPase Cdc42 play roles in mediating the effect of PtdIns(3,4,5)P-3 on F-actin assembly. Moreover, the spatial and temporal dynamics of PtdIns(3,4,5)P-3 is impaired by depletion of MATER or Filia, two oocyte proteins encoded by maternal effect genes. Thus, PtdIns(3,4,5)P-3 is synthesized during meiotic maturation and acts upstream of Cdc42 and Fmn2, but downstream of MATER/Filia proteins to regulate the F-actin organization and spindle translocation to the cortex during mouse oocyte meiosis.
关键词	Oocyte Meiosis Ptdins(3 Spindle Translocation 4 Filamentous Actin 5)P-3 Cdc42
资助者	This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng].
收录类别	SCI
语种	英语
资助者	This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng]. ; This work was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, USA (to J. D.); and the Natural Science Foundation of China [grant number 31071274 to P. Zheng].
WOS记录号	WOS:000317281700002
引用统计	被引频次：16[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7431
专题	科研部门_哺乳动物胚胎发育（郑萍）遗传资源与进化国家重点实验室
通讯作者	zhengp@mail.kiz.ac.cn; jurrien@helix.nih.gov
作者单位	1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China 2.Yunnan Key Laboratory of Animal Reproductive Biology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
推荐引用方式 GB/T 7714	Zheng P*,Baibakov B,Wang XH,et al. PtdIns(3,4,5)P-3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes[J]. JOURNAL OF CELL SCIENCE,2013,126(3):715-721.
APA	Zheng P,Baibakov B,Wang XH,Dean J,zhengp@mail.kiz.ac.cn,&jurrien@helix.nih.gov.(2013).PtdIns(3,4,5)P-3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes.JOURNAL OF CELL SCIENCE,126(3),715-721.
MLA	Zheng P*,et al."PtdIns(3,4,5)P-3 is constitutively synthesized and required for spindle translocation during meiosis in mouse oocytes".JOURNAL OF CELL SCIENCE 126.3(2013):715-721.

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