Accumulation of mtDNA variations in human single CD34(+) cells from maternally related individuals: Effects of aging and family genetic background

KIZ OpenIR > 科研部门 > 疾病机理遗传学和进化医学学科组（姚永刚）

	Accumulation of mtDNA variations in human single CD34(+) cells from maternally related individuals: Effects of aging and family genetic background
	Yao YG*1,2; Kajigaya S 1; Feng XM 1; Samsel L 1; Mccoy JP 1; Torelli G 3; Young NS 1; ygyaozh@gmail.com
	2013
发表期刊	STEM CELL RESEARCH
卷号	10 期号:3 页码:361-370
合作性质	其它
摘要	Marked sequence variation in the mtDNA control region has been observed in human single CD34(+) cells, which persist in vivo and are present also in differentiated hematopoietic cells. In this study, we analyzed 5071 single CD34(+) cells from 49 individuals (including 31 maternally related members from four families and 18 unrelated donors) in order to determine the mutation spectrum within the mtDNA control region in single cells, as related to aging and family genetic background. Many highly mutated sites among family members were hypervariable sites in the mtDNA control region. Further, CD34(+) cells from members of the same family also shared several unique mtDNA variants, suggesting pedigree-specific occurrence of these variants. Overall age-related accumulation of mtDNA mutations in CD34(+) cells varied in different families, suggesting a specific accumulation pattern, which might be modulated by family genetic background. Our current findings have implications for the occurrence of mtDNA mutations in hematopoietic stem cells and progenitors.
资助者	This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021).
收录类别	SCI
语种	英语
资助者	This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021). ; This research was supported (in part) by the Intramural Research Program of the NIH, NHLBI. Y.-G.Y was supported by the Ministry of Science and Technology of China (2011CB910900), Yunnan Province (2009CI119), and Natural Science Foundation of China (30925021).
WOS记录号	WOS:000318330400009
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7463
专题	科研部门_疾病机理遗传学和进化医学学科组（姚永刚）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	ygyaozh@gmail.com
作者单位	1.Hematology Branch and Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA 2.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China 3.Dipartimento di Oncologia ed Ematologia, Università di Modena e Reggio Emilia, Policlinico, Via del Pozzo 71, Modena 41100, Italy
推荐引用方式 GB/T 7714	Yao YG*,Kajigaya S,Feng XM,et al. Accumulation of mtDNA variations in human single CD34(+) cells from maternally related individuals: Effects of aging and family genetic background[J]. STEM CELL RESEARCH,2013,10(3):361-370.
APA	Yao YG*.,Kajigaya S.,Feng XM.,Samsel L.,Mccoy JP.,...&ygyaozh@gmail.com.(2013).Accumulation of mtDNA variations in human single CD34(+) cells from maternally related individuals: Effects of aging and family genetic background.STEM CELL RESEARCH,10(3),361-370.
MLA	Yao YG*,et al."Accumulation of mtDNA variations in human single CD34(+) cells from maternally related individuals: Effects of aging and family genetic background".STEM CELL RESEARCH 10.3(2013):361-370.

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