Evolution of neurotransmitter gamma-aminobutyric acid,glutamate and their receptors

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	Evolution of neurotransmitter gamma-aminobutyric acid,glutamate and their receptors
	Gou ZH 1,2; Wang X 1,2; Wang W*1; wwang@mail.kiz.ac.cn
	2012
发表期刊	Zoological Research
卷号	33 期号:E5-6 页码:E75−E81
合作性质	其它
摘要	Gamma-aminobutyric acid (GABA) and glutamate are two important amino acid neurotransmitters widely present in the nervous systems of mammals, insects, round worm, and platyhelminths, while their receptors are quite diversified across different animal phyla. However, the evolutionary mechanisms between the two conserved neurotransmitters and their diversified receptors remain elusive, and antagonistic interactions between GABA and glutamate signal transduction systems, in particular, have begun to attract significant attention. In this review, we summarize the extant results on the origin and evolution of GABA and glutamate, as well as their receptors, and analyze possible evolutionary processes and phylogenetic relationships of various GABAs and glutamate receptors. We further discuss the evolutionary history of Excitatory/Neutral Amino Acid Transporter (EAAT), a transport protein, which plays an important role in the GABA-glutamate “yin and yang” balancedregulation. Finally, based on current advances, we propose several potential directions of future research.
关键词	Gamma-aminobutyric Acid Glutamate Neurotransmitter Receptor Evolution
收录类别	其他
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7648
专题	基因起源组遗传资源与进化国家重点实验室
通讯作者	wwang@mail.kiz.ac.cn
作者单位	1.CAS-Max Planck Junior Research Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences (CAS), Kunming 650223, China 2.Graduate School of the Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式 GB/T 7714	Gou ZH,Wang X,Wang W*,et al. Evolution of neurotransmitter gamma-aminobutyric acid,glutamate and their receptors[J]. Zoological Research,2012,33(E5-6):E75−E81.
APA	Gou ZH,Wang X,Wang W*,&wwang@mail.kiz.ac.cn.(2012).Evolution of neurotransmitter gamma-aminobutyric acid,glutamate and their receptors.Zoological Research,33(E5-6),E75−E81.
MLA	Gou ZH,et al."Evolution of neurotransmitter gamma-aminobutyric acid,glutamate and their receptors".Zoological Research 33.E5-6(2012):E75−E81.

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2013091710.pdf（494KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文