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	New Insights into the Pharmacological Chaperone Activity of C2-Substituted Glucoimidazoles for the Treatment of Gaucher Disease
	Li ZH1; Li TH1; Dai SX2; Xie XL1; Ma XF1; Zhao W1; Zhang WM3; Li J*1; Wang PG*1; jinglink@nankai.edu.cn; pwang@nankai.edu.cn
	2013
发表期刊	CHEMBIOCHEM
卷号	14期号:10页码:1239-1247
摘要	Clinical observations indicate that atypical antipsychotics, especially clozapine, induce obsessive-compulsive (OC) symptoms in schizophrenia patients. Recent data from neuroimaging and clinical trials suggest a role for altered glutamate neurotransmission in the etiology of OC disorder (OCD), and SLC1A1, GRIN2B, and GRIK2 have all been reported to regulate glutamate transmission and affect OCD pathophysiology.  This study aimed to determine whether SLC1A1, GRIN2B, and GRIK2 are associated with clozapine-induced OC symptoms.  A total of 250 clinically stable schizophrenia patients receiving clozapine treatment were recruited. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was used to evaluate the severity of OC symptoms. Based on their Y-BOCS scores, 250 patients were divided into the OC and non-OC groups (patients with or without OC symptoms, respectively). Additionally, three reported OCD susceptibility polymorphisms, SLC1A1 (rs2228622), GRIN2B (rs890), and GRIK2 (rs1556995), were genotyped.  Trends of association with OC symptoms were observed in rs2228622A and rs890T alleles. SLC1A1 and GRIN2B interaction was found in the significant two-locus gene-gene interaction model (p = 0.0021), using the multifactor dimensionality reduction method. Further analysis showed a significant interaction between SLC1A1 and GRIN2B on the Y-BOCS score (F (6, 137) = 7.650, p < 0.001), and individuals with AA/TT genotypes had a significantly higher mean Y-BOCS score than those with other genotypes, except AG/TT.  These results suggest that SLC1A1, GRIN2B, and interactions between the two may potentially confer a susceptibility to OC symptoms in schizophrenia patients receiving clozapine.
关键词	Clozapine Obsessive Compulsive Symptom Glutamate Transmission Gene-gene Interaction Schizophrenia
资助者	This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371).
收录类别	SCI
语种	英语
资助者	This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371). ; This work was supported by the Natural Science Foundation of China (No. 91013013, 31000371).
WOS记录号	WOS:000325849600015
引用统计	被引频次：16[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7703
专题	结构生物信息学 遗传资源与进化国家重点实验室
通讯作者	jinglink@nankai.edu.cn; pwang@nankai.edu.cn
作者单位	1.State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University 94 Weijin Road, Tianjin 300071 (P.R.China) 2.School of Life Sciences, University of Science and Technology of China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of Zoology, Chinese Academy of Sciences 32 Jiaochang Donglu Kunming, Yunnan 650223 (P.R. China) 3.Clinical Research Lab, Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College 5 Dongdan Santiao, Beijing 100730 (P.R. China)
推荐引用方式 GB/T 7714	Li ZH,Li TH,Dai SX,et al. New Insights into the Pharmacological Chaperone Activity of C2-Substituted Glucoimidazoles for the Treatment of Gaucher Disease[J]. CHEMBIOCHEM,2013,14(10):1239-1247.
APA	Li ZH.,Li TH.,Dai SX.,Xie XL.,Ma XF.,...&pwang@nankai.edu.cn.(2013).New Insights into the Pharmacological Chaperone Activity of C2-Substituted Glucoimidazoles for the Treatment of Gaucher Disease.CHEMBIOCHEM,14(10),1239-1247.
MLA	Li ZH,et al."New Insights into the Pharmacological Chaperone Activity of C2-Substituted Glucoimidazoles for the Treatment of Gaucher Disease".CHEMBIOCHEM 14.10(2013):1239-1247.

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bj01296552.pdf（1517KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文

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