Association of HSD17B3 and HSD3B1 Polymorphisms with Acne Vulgaris in Southwestern Han Chinese

	Association of HSD17B3 and HSD3B1 Polymorphisms with Acne Vulgaris in Southwestern Han Chinese
	Yang XY 1,2; Wu WJ 1; Yang C 2; Yang T 1; He JD 3; Yang ZQ 1; He L*1; heli2662@yahoo.com.cn
	2013
发表期刊	DERMATOLOGY
卷号	227 期号:3 页码:202-208
摘要	Acne vulgaris is a very common skin disorder. Previous studies have indicated that genetic background factors play key roles in the onset of acne. Our previous investigation implicated several genes in the androgen metabolism pathway with acne vulgaris in the Han Chinese population. Thus, we further investigated genes and genetic variants that play important roles in this pathway for their relationship with the pathology of acne. In this study, a total of 610 subjects, including 403 acne patients and 207 healthy controls, were genotyped for 15 single-nucleotide polymorphisnns in HSD3B1 and HSD17B3 genes. This study shows that rs6428829 in HSD3B1 was associated with acne vulgaris in Han patients from Southwest China, even after adjusting for age and sex. The GG genotype was associated with an increased risk of acne vulgaris (p < 0.05) and G allele carriers were associated with an increased risk of acne vulgaris (p < 0.05). In addition, the haplotype AAT in HSD3B1 significantly increased the risk of acne vulgaris in the case-control study (p < 0.05). Furthermore, for another gene in this pathway, HSD17B3, the haplotype H8 was significantly associated with an increased risk of acne vulgaris. Based on these analyses, our study indicates that the cutaneous androgen metabolism-regulated genes HSD3B1 and HSD17B3 increase the susceptibility to acne vulgaris in Han Chinese from Southwest China.
关键词	Acne Vulgaris Androgens Hsd17b3 Hsd3b1 Single-nucleotide Polymorphisms
收录类别	SCI
语种	英语
WOS记录号	WOS:000327675500003
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7747
专题	遗传资源与进化国家重点实验室
通讯作者	heli2662@yahoo.com.cn
作者单位	1.Department of Dermatology, First Affiliated Hospital of Kunming Medical University, and Institute of Dermatology & Venereology of Yunnan province, Kunming 650032, China 2.Winona Dermo-Cosmetology Center 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
推荐引用方式 GB/T 7714	Yang XY,Wu WJ,Yang C,et al. Association of HSD17B3 and HSD3B1 Polymorphisms with Acne Vulgaris in Southwestern Han Chinese[J]. DERMATOLOGY,2013,227(3):202-208.
APA	Yang XY.,Wu WJ.,Yang C.,Yang T.,He JD.,...&heli2662@yahoo.com.cn.(2013).Association of HSD17B3 and HSD3B1 Polymorphisms with Acne Vulgaris in Southwestern Han Chinese.DERMATOLOGY,227(3),202-208.
MLA	Yang XY,et al."Association of HSD17B3 and HSD3B1 Polymorphisms with Acne Vulgaris in Southwestern Han Chinese".DERMATOLOGY 227.3(2013):202-208.

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