| 其他摘要 | According to the DSM-Ⅳ, postpartum depression (PPD) is defined as a modifier similar to major depressive disorders (MDD). Owing to PPD being of short durations (weeks to months) and moderate symptoms (at least two items of mainly clinical manifestations in MDD), this leads to related research for PPD far beneath MDD. While, in fact, PPD can exert negative effects on both mothers and infants through disturbing their interaction processes, therefore it does harm much seriously than MDD. To probe the pathogenesis of PPD and develop effectively clinical interventions for PPD as soon as possible, are considered to being quite important issues. However, both mothers and infants are very susceptible to the postpartum period, by which the relevant research to PPD are restrained, and result to, up to now, no satisfactorily therapeutic methods of PPD being developed. The facts above also highlight the importance of animal models. The rodents are commonly used as model animals in studying PPD, but because there are great gaps on the reproductive characteristic between the rodents and the humans, and the biological factors being explored in the rodent models of PPD are quite simple, these make animal models of PPD based on the rodents unable to competent for systematically studying the ethology of PPD. The behavioral depression phenomena long before was found in the non-human primates, and still their physiological aspects and high brain functions are much more approaching to the humans’ than the rodents’, hence to develop the non-human primate models of PPD can be actually practical and very useful. The cynomolgus monkeys (Macaca fascicularis) are the important member of the Macaca，whose society is of high-organized hierarchy. In addition, their behavioral indexes are very rich, and their reproductive activity is not restricted by seasonal change. In view of this, the advantages above mentioned qualified the cynomolgus monkeys as the very potential tools in study of PPD. In present study, we chose the macaques as the subjects, and employed the typically depressive behavior, the huddle, indicative of behavioral depression postpartum. We found that few of the female adult cynomolgus monkeys in breeding group demonstrated behavioral depression postpartum. On the other hand, the mother monkeys in deliver are always companied by the loss of blood, which are suspected to be able to induce the occurrence of huddling. After removing this confounding factor, we preliminarily confirmed that the behavioral depression postpartum similar to PPD exists in the non-human primates. Based on the finding, we further analyzed the relationship of stressful events、cortisol in hair, and maternal relationship with the above PPD-related behavior phenomena in female adult cynomolgus monkeys. The results revealed that there were no differences in both stressful events and hair cortisol between behavioral depression postpartum group and non-behavioral depression postpartum group we observed, as abnormal maternal relationship emerged with the behavioral depression postpartum mentioned above，which further proved poor maternal relationship linked to PPD. |
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