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	Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells
	Au KY1; Wang RR2; Wong YT1; Wong KB1; Zheng YT*2; Shaw PC*1; zhengyt@mail.kiz.ac.cn; pcshaw@cuhk.edu.hk
	2014
发表期刊	BIOCHIMICA ET BIOPHYSICA ACTA
卷号	1840期号:3页码:958-963
合作性质	其它
摘要	Background: Ricin is a type II ribosome-inactivating protein (RIP) that potently inactivates eukaryotic ribosomes by removing a specific adenine residue at the conserved alpha-sarcin/ricin loop of 28S ribosomal RNA (rRNA). Here, we try to increase the specificity of the enzymatically active ricin A chain (RTA) towards human immunodeficiency virus type 1 (HIV-1) by adding a loop with HIV protease recognition site to RTA. Methods: HIV-specific RTA variants were constructed by inserting a peptide with HIV-protease recognition site either internally or at the C-terminal region of wild type RTA Cleavability of variants by viral protease was tested in vitro and in HIV-infected cells. The production of viral p24 antigen and syncytium in the presence of C-terminal variants was measured to examine the anti-HIV activities of the variants. Results: C-terminal RTA variants were specifically cleaved by HIV-1 protease both in vitro and in HIV-infected cells. Upon proteolysis, the processed variants showed enhanced antiviral effect with low cytotoxicity towards uninfected cells. Conclusions: RTA variants with HIV protease recognition sequence engineered at the C-terminus were cleaved and the products mediated specific inhibitory effect towards HIV replication. General significance: Current cocktail treatment of HIV infection fails to eradicate the virus from patients. Here we illustrate the feasibility of targeting an RIP towards HIV-infected cells by incorporation of HIV protease cleavage sequence. This approach may be generalized to other RIPs and is promising in drug design for combating HIV.
关键词	Ribosome-inactivating Protein Ricin Hiv Protease
资助者	Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483).
收录类别	SCI
语种	英语
资助者	Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483). ; Work in Hong Kong was supported by a grant from the Research Fund for the Control of Infectious Diseases (Project No. 10090452). Work in Kunming was supported by the Key Scientific and Technological Program of China (2012ZX10001-006; 2012ZX10001-007) and NSFC (81001462, 81102483).
WOS记录号	WOS:000331344700004
引用统计	被引频次：7[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7833
专题	科研部门_分子免疫药理学（郑永唐） 科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	zhengyt@mail.kiz.ac.cn; pcshaw@cuhk.edu.hk
作者单位	1.Biochemistry Programme and Centre for Protein Science and Crystallography, School of Life Sciences, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
推荐引用方式 GB/T 7714	Au KY,Wang RR,Wong YT,et al. Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells[J]. BIOCHIMICA ET BIOPHYSICA ACTA,2014,1840(3):958-963.
APA	Au KY.,Wang RR.,Wong YT.,Wong KB.,Zheng YT*.,...&pcshaw@cuhk.edu.hk.(2014).Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells.BIOCHIMICA ET BIOPHYSICA ACTA,1840(3),958-963.
MLA	Au KY,et al."Engineering a switch-on peptide to ricin A chain for increasing its specificity towards HIV-infected cells".BIOCHIMICA ET BIOPHYSICA ACTA 1840.3(2014):958-963.

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2014040404.pdf（542KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文

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