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	Maternal separation exaggerates spontaneous recovery of extinguished contextual fear in adult female rats
	Xiong GJ1,2; Yang Y3; Wang LP1; Xu L*1; Mao RR*1; lxu@vip.163.com; talktomaomao@163.com
	2014
发表期刊	BEHAVIOURAL BRAIN RESEARCH
卷号	269期号:X页码:75-80
合作性质	其它
摘要	Early life stress increases the risk of posttraumatic stress disorders (PTSD). Patients with PTSD show impaired extinction of traumatic memory, and in women, this occurs more often when PTSD is preceded by child trauma. However, it is still unclear how early life stress accounts for extinction impairment. Here, we studied the effects of maternal separation (MS, postnatal day 2 to 14) on contextual fear extinction in adult female rats. Additionally, to examine changes in synaptic function affected by MS, we measured long-term potentiation (LTP) in prefrontal cortex and hippocampus in vitro, both of which have been implicated in fear extinction. We found that adult female rats had been subjected to MS exhibited significant spontaneous recovery of fear to the extinguished context. Furthermore, MS exposure resulted in LTP impairment in both infralimbic prefrontal cortex layer 2/3-layer 5 and hippocampal SC-CA1 pathways. Interestingly, no obvious effects of MS on contextual fear conditioning, fear recall as well as extinction training and recall were observed. Innate fear in the elevated plus maze or open field test remained nearly unaffected. These findings provided the first evidence that MS may exaggerate spontaneous recovery after contextual fear extinction, for which LTP impairment in the medial prefrontal cortex and hippocampus may be responsible, thereby possibly leading to impaired extinction associated with PTSD.
关键词	Contextual Fear Extinction Female Long-term Potentiation Maternal Separation Spontaneous Recovery
资助者	This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104).
收录类别	SCI
语种	英语
资助者	This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104). ; This work was supported by National Basic Research Program of China (2013CB835103); NSFC-CIHR Joint Grant (81161120536); Strategic Priority Research Program of the Chinese Academy of Science (XDB02020002); National Natural Science Foundation of China (31100786, U1032605 and U1132602); Science and Technol- ogy Program of Yunnan Province (2013GA003 and 2010CD104).
WOS记录号	WOS:000337866400011
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7895
专题	科研部门_学习记忆的分子神经机制（徐林） 科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	lxu@vip.163.com; talktomaomao@163.com
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, and KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan 650223, China 2.University of Chinese Academy of Sciences, Beijing 100049, China 3.Department of Physiology, Kunming Medical University, Kunming, Yunnan 650500, China
推荐引用方式 GB/T 7714	Xiong GJ,Yang Y,Wang LP,et al. Maternal separation exaggerates spontaneous recovery of extinguished contextual fear in adult female rats[J]. BEHAVIOURAL BRAIN RESEARCH,2014,269(X):75-80.
APA	Xiong GJ.,Yang Y.,Wang LP.,Xu L*.,Mao RR*.,...&talktomaomao@163.com.(2014).Maternal separation exaggerates spontaneous recovery of extinguished contextual fear in adult female rats.BEHAVIOURAL BRAIN RESEARCH,269(X),75-80.
MLA	Xiong GJ,et al."Maternal separation exaggerates spontaneous recovery of extinguished contextual fear in adult female rats".BEHAVIOURAL BRAIN RESEARCH 269.X(2014):75-80.

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