| Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration | |
| Wen ZY1,2; Yan ZQ1; Hu KL3; Pang ZQ1; Cheng XF1; Guo LR1; Zhang QZ1; Jiang XG*1; Fang L*2; Lai R*4; xgjiang@shmu.edu.cn; fangliang2003@yahoo.com; rlai@mail.kiz.ac.cn | |
| 2011 | |
| 发表期刊 | JOURNAL OF CONTROLLED RELEASE
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| 卷号 | 151期号:2页码:131-138 |
| 合作性质 | 其它 |
| 摘要 | Odorranalectin (OL) was recently identified as the smallest lectin with much less immunogenicity than other members of the lectin family. In this study, to improve nose-to-brain drug delivery and reduce the immunogenicity of traditional lectin modified delivery system, OL was conjugated to poly(ethylene glycol)poly( lactic-co-glycolic acid) (PEG-PLGA) nanoparticles and its biorecognitive activity on nanoparticles was verified by haemagglutination tests. Nose-to-brain delivery characteristic of OL-conjugated nanoparticles (OL-NP) was investigated by in vivo fluorescence imaging technique using DiR as a tracer. Besides, urocortin peptide (UCN), as a macromolecular model drug, was incorporated into nanoparticles and evaluated for its therapeutic efficacy on hemiparkinsonian rats following intranasal administration by rotation behavior test, neurotransmitter determination and tyrosine hydroxylase (TH) test. The results suggested that OL modification increased the brain delivery of nanoparticles and enhanced the therapeutic effects of UCN-loaded nanoparticles on Parkinson's disease. In summary, the OL-NPs could be potentially used as carriers for nose-to-brain drug delivery, especially for macromolecular drugs, in the treatment of CNS disorders. |
| 关键词 | Odorranalectin Nose-to-brain Delivery Parkinson's Disease Urocortin Peptide Nanoparticles |
| 资助者 | This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) ; This work was supported by the grant from National Basic Research Program (2007CB935800) of China (973 Program), National Science and Technology Major Project (2009ZX09310-006) and National Natural Science Foundation of China (30772657) |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/7908 |
| 专题 | 科研部门_天然药物功能蛋白质学科组（赖仞） 科研部门_动物模型与人类重大疾病机理重点实验室 |
| 通讯作者 | xgjiang@shmu.edu.cn; fangliang2003@yahoo.com; rlai@mail.kiz.ac.cn |
| 作者单位 | 1.Department of Pharmaceutical Science, School of Pharmacy, Fudan University, Shanghai 201203, China 2.Department of Pharmaceutical Science, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning110016, China 3.Murad Research Center for Modernized Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China 4.Biotoxin Units of Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan, China |
| 推荐引用方式 GB/T 7714 | Wen ZY,Yan ZQ,Hu KL,et al. Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration[J]. JOURNAL OF CONTROLLED RELEASE,2011,151(2):131-138. |
| APA | Wen ZY.,Yan ZQ.,Hu KL.,Pang ZQ.,Cheng XF.,...&rlai@mail.kiz.ac.cn.(2011).Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration.JOURNAL OF CONTROLLED RELEASE,151(2),131-138. |
| MLA | Wen ZY,et al."Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration".JOURNAL OF CONTROLLED RELEASE 151.2(2011):131-138. |
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| 2014061701.pdf（1383KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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