E Protein Transcription Factors Are Required for the Development of CD4(+) Lineage T Cells

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	E Protein Transcription Factors Are Required for the Development of CD4(+) Lineage T Cells
	Jones-Mason ME 1; Zhao XD 2; Kappes D 6; Lasorella A 2,3,4; Iavarone A 2,3,5; Zhuang Y*1; yzhuang@duke.edu
	2012
发表期刊	IMMUNITY
卷号	36 期号:3 页码:348-361
摘要	The double-positive (DP) to single-positive (SP) transition during T cell development is initiated by downregulation of the E protein transcription factors HEB and E2A. Here, we have demonstrated that in addition to regulating the onset of this transition, HEB and E2A also play a separate role in CD4(+) lineage choice. Deletion of HEB and E2A in DP thymocytes specifically blocked the development of CD4(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 allowed CD4(+) T cell development but blocked CD8(+) lineage development. Analysis of the CD4(+) lineage transcriptional regulators ThPOK and Gata3 placed HEB and E2A upstream of CD4(+) lineage specification. These studies identify an important role for E proteins in the activation of CD4(+) lineage differentiation as thymocytes undergo the DP to SP transition.
收录类别	SCI
语种	英语
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7938
专题	科研共享资源
通讯作者	yzhuang@duke.edu
作者单位	1.Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA 2.Institute for Cancer Genetics,Columbia University Medical Center, New York, NY 10032, USA 3.Department of Pathology,Columbia University Medical Center, New York, NY 10032, USA 4.Department of Pediatrics,Columbia University Medical Center, New York, NY 10032, USA 5.Department of Neurology,Columbia University Medical Center, New York, NY 10032, USA 6.Fox Chase Cancer Center, Philadelphia, PA 19111, USA
推荐引用方式 GB/T 7714	Jones-Mason ME,Zhao XD,Kappes D,et al. E Protein Transcription Factors Are Required for the Development of CD4(+) Lineage T Cells[J]. IMMUNITY,2012,36(3):348-361.
APA	Jones-Mason ME.,Zhao XD.,Kappes D.,Lasorella A.,Iavarone A.,...&yzhuang@duke.edu.(2012).E Protein Transcription Factors Are Required for the Development of CD4(+) Lineage T Cells.IMMUNITY,36(3),348-361.
MLA	Jones-Mason ME,et al."E Protein Transcription Factors Are Required for the Development of CD4(+) Lineage T Cells".IMMUNITY 36.3(2012):348-361.

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