中国科学院昆明动物研究所机构知识库

QQ客服 官方微博 反馈留言

	Proteins and Id2 converge on p57(Kip2) to regulate cell cycle in neural cells
	Rothschild G1; Zhao XD1; Iavarone A*1,2,3; Lasorella A1,2,4; ai2102@columbia.edu
	2006
发表期刊	MOLECULAR AND CELLULAR BIOLOGY
卷号	26期号:11页码:4351-4361
摘要	A precise balance between proliferation and differentiation must be maintained during neural development to obtain the correct proportion of differentiated cell types in the adult nervous system. The basic helix-loop-helix (hHLH) transcription factors known as E proteins and their natural inhibitors, the Id proteins, control the timing of differentiation and terminal exit from the cell cycle. Here we show that progression into S phase of human neuroblastoma cells is prevented by E proteins and promoted by W. Cyclin-dependent kinase inhibitors (CKI) have been identified as key effectors of cell cycle arrest in differentiating cells. However, p57(Kip2) is the only CKI that is absolutely required for normal development. Through the use of global gene expression analysis in neuroblastoma cells engineered to acutely express the E protein E47 and W, we find that p57(Kip2) is a target of E47. Consistent with the role of Id proteins, Id2 prevents activation of p57(Kip2) expression, and the retinoblastoma tumor suppressor protein, a known Id2 inhibitor, counters this activity. The strong E47-mediated inhibition of entry into S phase is entirely reversed in cells in which expression of p57(Kip2) is silenced by RNA interference. During brain development, expression of p57(Kip2) is opposite that of Id2. Our findings identify p57(Kip2) as a functionally relevant target recruited by bHLH transcription factors to induce cell cycle arrest in developing neuroblasts and suggest that deregulated expression of Id proteins may be an epigenetic mechanism to silence expression of this CKI in neural tumors.
资助者	This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA).
收录类别	SCI
语种	英语
资助者	This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA). ; This work was supported by grants from NIH-NCI to A.L. (R01- CA101644) and A.I. (R01-CA85628) and from the Charlotte Geyer Foundation (A.I.). G.R. was supported by a training grant from the NIH (Ruth L. Kirschstein NRSA).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7939
专题	科研共享资源
通讯作者	ai2102@columbia.edu
作者单位	1.Institute for Cancer Genetics, College of Physicians and Surgeons of Columbia University, New York, New York 10032 2.Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York 10032 3.Department of Neurology, College of Physicians and Surgeons of Columbia University, New York, New York 10032 4.Department of Pediatrics,College of Physicians and Surgeons of Columbia University, New York, New York 10032
推荐引用方式 GB/T 7714	Rothschild G,Zhao XD,Iavarone A*,et al. Proteins and Id2 converge on p57(Kip2) to regulate cell cycle in neural cells[J]. MOLECULAR AND CELLULAR BIOLOGY,2006,26(11):4351-4361.
APA	Rothschild G,Zhao XD,Iavarone A*,Lasorella A,&ai2102@columbia.edu.(2006).Proteins and Id2 converge on p57(Kip2) to regulate cell cycle in neural cells.MOLECULAR AND CELLULAR BIOLOGY,26(11),4351-4361.
MLA	Rothschild G,et al."Proteins and Id2 converge on p57(Kip2) to regulate cell cycle in neural cells".MOLECULAR AND CELLULAR BIOLOGY 26.11(2006):4351-4361.

条目包含的文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
2014070702.pdf（1003KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文

个性服务

推荐该条目

保存到收藏夹

查看访问统计

导出为Endnote文件

谷歌学术

谷歌学术中相似的文章

[Rothschild G]的文章

[Zhao XD]的文章

[Iavarone A*]的文章

百度学术

百度学术中相似的文章

[Rothschild G]的文章

[Zhao XD]的文章

[Iavarone A*]的文章

必应学术

必应学术中相似的文章

[Rothschild G]的文章

[Zhao XD]的文章

[Iavarone A*]的文章

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。