Id proteins synchronize sternness and anchorage to the niche of neural stern cells

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	Id proteins synchronize sternness and anchorage to the niche of neural stern cells
	Niola F 1,8,9; Zhao XD 1,8,9; Singh D 1; Castano A 1; Sullivan R 1; Lauria M 2,9; Nam HS 3,9; Zhuang Y 4; Benezra R 3; Bernardo DD 2; Iavarone A1,5,6; Lasorella A1,6,7; ai2102@columbia.edu or al2179@columbia.edu
	2012
发表期刊	NATURE CELL BIOLOGY
卷号	14 期号:5 页码:477-U80
摘要	Stem-cell functions require activation of stem-cell-intrinsic transcriptional programs and extracellular interaction with a niche microenvironment. How the transcriptional machinery controls residency of stem cells in the niche is unknown. Here we show that Id proteins coordinate stem-cell activities with anchorage of neural stem cells (NSCs) to the niche. Conditional inactivation of three Id genes in NSCs triggered detachment of embryonic and postnatal NSCs from the ventricular and vascular niche, respectively. The interrogation of the gene modules directly targeted by Id deletion in NSCs revealed that Id proteins repress bHLH-mediated activation of Rap1GAP, thus serving to maintain the GTPase activity of RAP1, a key mediator of cell adhesion. Preventing the elevation of the Rap1GAP level countered the consequences of Id loss on NSC niche interaction and stem-cell identity. Thus, by preserving anchorage of NSCs to the extracellular environment, Id activity synchronizes NSC functions to residency in the specialized niche.
资助者	This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento
收录类别	SCI
语种	英语
资助者	This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento ; This work was supported by National Cancer Institute grants R01CA101644 and R01CA131126 (A.L.), R01CA085628 and R01CA127643 (A.I.) and National Institute of Neurological Disorders and Stroke R01NS061776 (A.I.). F.N. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7942
专题	科研共享资源
通讯作者	ai2102@columbia.edu or al2179@columbia.edu
作者单位	1.Institute for Cancer Genetics, Columbia University Medical Center, New York, New York 10032, USA 2.Telethon Institute of Genetics and Medicine (TIGEM), Naples 80131, Italy 3.Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA 4.Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA 5.Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA. 6.Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA 7.Department of Pediatrics, Columbia University Medical Center, New York, New York 10032, USA 8.These authors contributed equally to this work. 9.Present addresses: Neuroscience and Brain Technologies, Fondazione Istituto Italiano di Tecnologia, Genoa 16163, Italy (F.N.); Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China (X.Z.); The Microsoft Research—University of Trento Centre for Computational and Systems Biology, I-38068 Rovereto (TN), Italy (M.L.); Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA (H-s.N.).
推荐引用方式 GB/T 7714	Niola F,Zhao XD,Singh D,et al. Id proteins synchronize sternness and anchorage to the niche of neural stern cells[J]. NATURE CELL BIOLOGY,2012,14(5):477-U80.
APA	Niola F.,Zhao XD.,Singh D.,Castano A.,Sullivan R.,...&ai2102@columbia.edu or al2179@columbia.edu.(2012).Id proteins synchronize sternness and anchorage to the niche of neural stern cells.NATURE CELL BIOLOGY,14(5),477-U80.
MLA	Niola F,et al."Id proteins synchronize sternness and anchorage to the niche of neural stern cells".NATURE CELL BIOLOGY 14.5(2012):477-U80.

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