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	Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum
	D'Arca D1; Zhao XD1; Xu WM1; Ramirez-Martinez NC1; Iavarone A&1,2,3; Lasorella A*1,2,4; ai2102@columbia.edu; al2179@ columbia.edu
	2010
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷号	107期号:13页码:5875-5880
摘要	We have generated a knockout mouse strain in which the gene coding for the ubiquitin ligase Huwe1 has been inactivated in cerebellar granule neuron precursors (CGNPs) and radial glia. These mice have a high rate of postnatal lethality and profound cerebellar abnormalities. The external granule layer of the cerebellum, which contains CGNPs, is expanded and displays aberrant proliferation and impaired differentiation of the progenitor cell population. The uncontrolled proliferation of the CGNPs is associated with accumulation of the N-Myc oncoprotein, a substrate of Huwe1, and con-sequent activation of the signaling events downstream to N-Myc. Furthermore, loss of Huwe1 in Bergmann glia leads to extensive disorganization of this cell population with layering aberrations, severe granule neuron migration defects, and persistence of ectopic clusters of granule neurons in the external granule layer. Our findings uncover an unexpected role for Huwe1 in regulating Berg-mann glia differentiation and indicate that this ubiquitin ligase orchestrates the programming of the neural progenitors that give rise to neurons and glia in the cerebellum.
关键词	Hect Domain Cell Migration Nervous System Development Tumor Suppressor
资助者	This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy.
收录类别	SCI
语种	英语
资助者	This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy. ; This work was supported by grants from the National Institutes of Health–National Cancer Institute to A.L. (R01CA131126) and A.I. (R01CA085628). D.D. is supported by fellowships from Provincia di Benevento/Ministero del Lavoro, Italy.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7946
专题	科研共享资源
通讯作者	ai2102@columbia.edu; al2179@ columbia.edu
作者单位	1.Institute for Cancer Genetics and Departments of Columbia University Medical Center, New York, NY 10032 2.Pathology,Columbia University Medical Center, New York, NY 10032 3.Neurology,Columbia University Medical Center, New York, NY 10032 4.Pediatrics, Columbia University Medical Center, New York, NY 10032
推荐引用方式 GB/T 7714	D'Arca D,Zhao XD,Xu WM,et al. Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(13):5875-5880.
APA	D'Arca D.,Zhao XD.,Xu WM.,Ramirez-Martinez NC.,Iavarone A&.,...&al2179@ columbia.edu.(2010).Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(13),5875-5880.
MLA	D'Arca D,et al."Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellum".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.13(2010):5875-5880.

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2014070709.pdf（2588KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文

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