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The transcriptional network for mesenchymal transformation of brain tumours
Carro MS1; Lim WK2,3; Alvarez MJ3,4; Aldape K12; Califano A*1,2,3,4; Iavarone A1,5,7; Bollo RJ8; Zhao XD1; Snyder EY9; Sulman EP10; Anne SL1; Doetsch F5; Colman H11; Lasorella A*1,5,6; califano@c2b2.columbia.edu; ai2102@columbia.edu
2010
发表期刊NATURE
卷号463期号:7279页码:318-U68
合作性质其它
摘要The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma, but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBP beta and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBP beta and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage, whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma, expression of C/EBP beta and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells.
资助者This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures.
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资助者This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures. ; This work was supported by National Institute of Health grants R01CA109755 (A.C.), R01CA101644 (A.L.), R01CA085628 and R01NS061776 (A.I.), NCI Grand Opportunities TDDN Network 1RC2CA148308-01 (A.C.), In Silico Research Centre of Excellence NCI-caBIG 29XS192 (A.C.), National Centers for Biomedical Computing NIH Roadmap Initiative U54CA121852 (A.C.) and National Institute of General Medical Sciences grant P20GM075059 (E.Y.S.). M.S.C. is supported by a fellowship from the Italian Ministry of Welfare/Provincia di Benevento and S.L.A. by a fellowship from Fondation de Recherche Medicale. We thank N. Ramirez-Martinez for technical assistance with mouse husbandry and in vivo procedures.
文献类型期刊论文
条目标识符http://ir.kiz.ac.cn/handle/152453/7948
专题科研共享资源
通讯作者califano@c2b2.columbia.edu; ai2102@columbia.edu
作者单位1.Institute for Cancer Genetics,Columbia University Medical Center, New York, New York 10032, USA
2.Department of Biomedical Informatics,Columbia University Medical Center, New York, New York 10032, USA
3.Center for Computational Biology and Bioinformatics,Columbia University Medical Center, New York, New York 10032, USA
4.Joint Centers for Systems Biology,Columbia University Medical Center, New York, New York 10032, USA
5.Department of Pathology,Columbia University Medical Center, New York, New York 10032, USA
6.Department of Pediatrics,Columbia University Medical Center, New York, New York 10032, USA
7.Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA
8.Department of Neurosurgery, New York University School ofMedicine&NYULangone MedicalCenter,NewYork,NewYork10016,USA
9.Burnham Institute forMedicalResearch,LaJolla,California92037, USA
10.Division of Radiation Oncology,M.D. Anderson Cancer Center, Houston,Texas 77030,USA
11.Department of Neuro-Oncology,M.D. Anderson Cancer Center, Houston,Texas 77030,USA
12.Department of Pathology, M.D. Anderson Cancer Center, Houston,Texas 77030,USA
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GB/T 7714		 Carro MS,Lim WK,Alvarez MJ,et al. The transcriptional network for mesenchymal transformation of brain tumours[J]. NATURE,2010,463(7279):318-U68.
APA Carro MS.,Lim WK.,Alvarez MJ.,Aldape K.,Califano A*.,...&ai2102@columbia.edu.(2010).The transcriptional network for mesenchymal transformation of brain tumours.NATURE,463(7279),318-U68.
MLA Carro MS,et al."The transcriptional network for mesenchymal transformation of brain tumours".NATURE 463.7279(2010):318-U68.
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