Tongshu Capsule Down-Regulates the Expression of Estrogen Receptor alpha and Suppresses Human Breast Cancer Cell Proliferation

KIZ OpenIR > 科研部门 > 肿瘤生物学（陈策实）

	Tongshu Capsule Down-Regulates the Expression of Estrogen Receptor alpha and Suppresses Human Breast Cancer Cell Proliferation
	Du CZ 1; Li Z 2; Wang S 1; Zhou ZM 1; Wang JK 3; Dong J 2; Chen CS*1; chenc@mail.kiz.ac.cn
	2014
发表期刊	PLOS ONE
卷号	9 期号:8 页码:e104261
合作性质	其它
摘要	The Tongshu Capsule (TSC) is a prevalent form of traditional Chinese medicine widely used for its purported effects in treating mammary gland hyperplasia and inflammation. Though successful in several clinical studies, there is no clear evidence as to why TSC has a positive treatment effect, and little known about underlying mechanism that may account for it. In this study, we examined the effects of TSC and found that it has a comparatively strong growth inhibition on ER alpha positive breast cancer cells. TSC seems to cause G1 cell cycle arrest instead of apoptosis. Interestingly, TSC also down-regulated the expression of ER alpha and Cyclin D1. Consistently, TSC suppressed E2 mediated ER alpha downstream gene expression and cell proliferation in ER alpha positive breast cancer cell lines MCF7 and T47D. Depletion of ER alpha partially abolished the effects of TSC on the decrease of Cyclin D1 and cell viability. Our findings suggest that TSC may have therapeutic effects on ER alpha positive breast cancers and moreover that TSC may suppress breast epithelial cell proliferation by inhibiting the estrogen pathway.
资助者	This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114).
收录类别	SCI
语种	英语
资助者	This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114). ; This study was partially funded by Yunnan Institute of Materia Medica, which is the manufacturer of Tongshu Capsule. This funder provided support in the form of salaries for author JW, but did not have any additional role in the study design, data collection and analysis, decision to publish, orpreparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section. This study was also supported in part by National Nature Science Foundation of China (81120108019, U1132605, and 81325016), and a grant from the Yunnan Province High-Profile Scientist Program (2010CI114).
WOS记录号	WOS:000339993900054
引用统计	被引频次：4[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/7992
专题	科研部门_肿瘤生物学（陈策实）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	chenc@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China 2.First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China 3.Yunnan Institute of Materia Medica, Kunming, Yunnan, China
推荐引用方式 GB/T 7714	Du CZ,Li Z,Wang S,et al. Tongshu Capsule Down-Regulates the Expression of Estrogen Receptor alpha and Suppresses Human Breast Cancer Cell Proliferation[J]. PLOS ONE,2014,9(8):e104261.
APA	Du CZ.,Li Z.,Wang S.,Zhou ZM.,Wang JK.,...&chenc@mail.kiz.ac.cn.(2014).Tongshu Capsule Down-Regulates the Expression of Estrogen Receptor alpha and Suppresses Human Breast Cancer Cell Proliferation.PLOS ONE,9(8),e104261.
MLA	Du CZ,et al."Tongshu Capsule Down-Regulates the Expression of Estrogen Receptor alpha and Suppresses Human Breast Cancer Cell Proliferation".PLOS ONE 9.8(2014):e104261.

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2014082905.pdf（1517KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文