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KIZ OpenIR  > 科研部门  > 离子通道药物研发中心（杨建）
Age-Related Homeostatic Midchannel Proteolysis of Neuronal L-type Voltage-Gated Ca2+ Channels
Michailidis IE1; Abele-Henckels K1; Zhang WK1; Lin BC1; Yu Y1; Geyman LS1; Ehlers MD2; Pnevmatikakis EA3; Yang J*1,4; jy160@columbia.edu
2014
发表期刊NEURON
卷号82期号:5页码:1045-1057
合作性质其它
摘要Neural circuitry and brain activity depend critically on proper function of voltage-gated calcium channels (VGCCs), whose activity must be tightly controlled. We show that the main body of the pore-forming alpha(1) subunit of neuronal L-type VGCCs, Ca(v)1.2, is proteolytically cleaved, resulting in Ca(v)1.2 fragment channels that separate but remain on the plasma membrane. This "midchannel'' proteolysis is regulated by channel activity, involves the Ca2+-dependent protease calpain and the ubiquitin-proteasome system, and causes attenuation and biophysical alterations of VGCC currents. Recombinant Ca(v)1.2 fragment channels mimicking the products of midchannel proteolysis do not form active channels on their own but, when properly paired, produce currents with distinct biophysical properties. Midchannel proteolysis increases dramatically with age and can be attenuated with an L-type VGCC blocker in vivo. Midchannel proteolysis represents a novel form of homeostatic negative-feedback processing of VGCCs that could profoundly affect neuronal excitability, neurotransmission, neuroprotection, and calcium signaling in physiological and disease states.
资助者This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer.
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资助者This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer. ; This work was supported by National Institutes of Health grants NS053494 and NS045383 (to J.Y.), an Established Investigator Award of the American Heart Association (to J.Y.), the Top Talents Program of Yunnan Province, China (to J.Y.), and a postdoctoral fellowship (0625908T) from the American Heart Association (to I.E.M.). M.D.E. is an employee and shareholder of Pfizer.
WOS记录号WOS:000337359800012
引用统计
文献类型期刊论文
条目标识符http://ir.kiz.ac.cn/handle/152453/8039
专题科研部门_离子通道药物研发中心（杨建）
通讯作者jy160@columbia.edu
作者单位1.Department of Biological Sciences, Columbia University, New York, NY 10027, USA
2.Neuroscience Research Unit, Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA
3.Department of Statistics, Columbia University, New York, NY 10027, USA
4.Ion Channel Research and Drug Development Center, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
推荐引用方式
GB/T 7714		 Michailidis IE,Abele-Henckels K,Zhang WK,et al. Age-Related Homeostatic Midchannel Proteolysis of Neuronal L-type Voltage-Gated Ca2+ Channels[J]. NEURON,2014,82(5):1045-1057.
APA Michailidis IE.,Abele-Henckels K.,Zhang WK.,Lin BC.,Yu Y.,...&jy160@columbia.edu.(2014).Age-Related Homeostatic Midchannel Proteolysis of Neuronal L-type Voltage-Gated Ca2+ Channels.NEURON,82(5),1045-1057.
MLA Michailidis IE,et al."Age-Related Homeostatic Midchannel Proteolysis of Neuronal L-type Voltage-Gated Ca2+ Channels".NEURON 82.5(2014):1045-1057.
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