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	Recovery of behavioral symptoms in hemi-parkinsonian rhesus monkeys through combined gene and stem cell therapy
	Zhou Y1; Sun MS1; Li HJ*1; Yan M1; He ZL1; Wang WJ2; Wang WP3; Lu SY1; lihj6912@hotmail.com
	2013
发表期刊	CYTOTHERAPY
卷号	15期号:4页码:467-480
合作性质	其它
摘要	Background aims. The use of adipose mesenchymal stromal cells (ASCs) in cellular and genic therapy has attracted considerable attention as a possible treatment for neurodegenerative disorders, including Parkinson disease. However, the effects of gene therapy combined with intracerebral cell transplantation have not been well defined. Recent studies have demonstrated the respective roles of LIM homeobox transcription factor 1, alpha (LMX1A) and Neurturin (NTN) in the commitment of embryonic stem cells (ESCs) to a midbrain dopaminergic neuronal fate and the commitment of mesenchymal stromal cells to cells supporting the nutrition and protection of neurons. Methods. We investigated a novel in vitro neuronal differentiation strategy with the use of LMX1A and Neurturin. We were able to elicit a neural phenotype regarding cell morphology, specific gene/protein expression and physiological function. Neuronal-primed ASCs derived from rhesus monkey (rASCs) combined with adenovirus containing NTN and tyrosine hydroxylase (TH) (Ad-NTN-TH) were implanted into the striatum and substantia nigra of methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-lesioned hemi-parkinsonian rhesus monkeys. Monkeys were monitored with the use of behavioral tests and health measures until the fourth month after implantation. Results. The differentiated cells transcribed and expressed a variety of dopaminergic neuron-specific genes involved in the SHH/LMX1A pathway. Single-photon emission computed tomography analysis and postmortem analysis revealed that the grafting of rASCs combined with Ad-NTN-TH had neuroprotective effects compared with Ad-NTN-TH or rASCs alone. Behavioral measures demonstrated autograft survival and symptom amelioration. Conclusions. These findings may lead to cellular sources for autologous transplantation of Parkinson disease. Combined transplantation of Ad-NTN-TH and induced rASCs expressing LMX1A and NTN may be a better therapy candidate for the treatment of Parkinson disease.
关键词	Rhesus Adipose Stem Cells (Rascs) Th Differentiation Lmx1a Neurturin Neuron Parkinson Disease
资助者	This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003).
收录类别	SCI
语种	英语
资助者	This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003). ; This research was financially supported by the Re- search Fund for Doctor Innovation of Beijing Union Medical College; Science and Technology Pro- ject of Yunnan Province (2012AE001, 2007C0012Z); National Natural Science Foundation of China (30971003).
WOS记录号	WOS:000316535400008
引用统计	被引频次：16[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/8090
专题	分子免疫生物学
通讯作者	lihj6912@hotmail.com
作者单位	1.Institute of Medical Biology, Peking Union Medical College, Chinese Academy of Medical Science, Kunming, China 2.Kunming Institute of Zoology, CAS, Kunming, China 3.First People’s Hospital of Yunnan Province, Kunming, China
推荐引用方式 GB/T 7714	Zhou Y,Sun MS,Li HJ*,et al. Recovery of behavioral symptoms in hemi-parkinsonian rhesus monkeys through combined gene and stem cell therapy[J]. CYTOTHERAPY,2013,15(4):467-480.
APA	Zhou Y.,Sun MS.,Li HJ*.,Yan M.,He ZL.,...&lihj6912@hotmail.com.(2013).Recovery of behavioral symptoms in hemi-parkinsonian rhesus monkeys through combined gene and stem cell therapy.CYTOTHERAPY,15(4),467-480.
MLA	Zhou Y,et al."Recovery of behavioral symptoms in hemi-parkinsonian rhesus monkeys through combined gene and stem cell therapy".CYTOTHERAPY 15.4(2013):467-480.

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2014101320.pdf（1936KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文

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