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	Interleukin-1 beta-mediated suppression of microRNA-101 and upregulation of enhancer of zeste homolog 2 is involved in particle-induced lung cancer
	Lei YM1; Zu YF2; Wang JY2; Bai S1; Shi YF1; Shi R1; Duan J1; Cui DL1; Chen JL1; Xiang Y*3; Dong J*1; yang_xiang000@hotmail.com; dongjian18@outlook.com
	2015
发表期刊	MEDICAL ONCOLOGY
卷号	32期号:1页码:e387
合作性质	其它
摘要	Lung cancer may be a result of complex factors. Small mineral particle is the well-known inducer of lung cancer. Previous study revealed the high morbidity of lung cancer in Xuan Wei in China, and the main cause of lung cancer is the use of smoky coal there. And it is generally accepted that chronic inflammation induced by small mineral particle may be a cause of lung cancer. But the relationship between chronic lung inflammation and lung cancer is largely unknown. In the present study, we found that silica particle was able to induce the secretion of interleukin-1 beta from a Xuan Wei lung cancer cell line, XWLC-05. At the same time, microRNA-101 (mir-101) was found to be downregulated by the treatment of silica particle. Interestingly, the interleukin 1 receptor antagonist and interleukin-1 beta antibody can reduce silica particle-induced downregulation of mir-101. Twenty-four Xuan Wei lung tumor tissues were collected to detect the expression level of mir-101 and enhancer of zeste homolog 2 (EZH2), which is the potential target of mir-101. The results showed that mir-101 was down-regulated and EZH2 were upregulated. Subsequently, the roles of mir-101 and EZH2 in tumor growth and progression in vitro were tested. Overexpression of mir-101 mimics was able to suppress the expression of EZH2 in XWLC-05 cells. And this resulted in the inhibited tumor cell growth and attenuated cell migration. The results in the present study showed that particle can induce the secretion of interleukin-1 beta. Interleukin-1 beta subsequently induces the downregulation of mir101, which may result in the upregulated level of EZH2, and occurrence of lung cancer. We for the first time proposed the role interleukin-1 beta-mir-101-EZH2 axes in the particle-induced lung cancer. Further study may be needed to decipher the detailed mechanism involved.
关键词	Xuan Wei Lung Cancer Interleukin-1 Beta Inflammasome Ezh2 Mir-101 Particle-induced Lung Cancer
资助者	This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193).
收录类别	SCI
语种	英语
资助者	This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193). ; This work was supported by grants from the Wu Jieping Medical Foundation (320.6750.12708), Yunnan Department of Natural Science and Kunming Medical University Co-funding (Grant Nos. 2011FB227, 2011FB208, 2014FB175, 2014FB193).
WOS记录号	WOS:000347775200048
引用统计
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/8203
专题	科研部门_生物毒素与人类疾病（张云） 科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	yang_xiang000@hotmail.com; dongjian18@outlook.com
作者单位	1.Department of Vip Surgery Ward and Department of Biotherapy, The First Affiliated Hospital of Kunming Medical University of Medical Science, Kunming 650032, Yunnan, China 2.Department of Oncology, Second People’s Hospital of Yunnan Province, Kunming 650221, Yunnan, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, The Chinese Academy of Sciences, 32 East Jiao Chang Road, Kunming 650223, Yunnan, China
推荐引用方式 GB/T 7714	Lei YM,Zu YF,Wang JY,et al. Interleukin-1 beta-mediated suppression of microRNA-101 and upregulation of enhancer of zeste homolog 2 is involved in particle-induced lung cancer[J]. MEDICAL ONCOLOGY,2015,32(1):e387.
APA	Lei YM.,Zu YF.,Wang JY.,Bai S.,Shi YF.,...&dongjian18@outlook.com.(2015).Interleukin-1 beta-mediated suppression of microRNA-101 and upregulation of enhancer of zeste homolog 2 is involved in particle-induced lung cancer.MEDICAL ONCOLOGY,32(1),e387.
MLA	Lei YM,et al."Interleukin-1 beta-mediated suppression of microRNA-101 and upregulation of enhancer of zeste homolog 2 is involved in particle-induced lung cancer".MEDICAL ONCOLOGY 32.1(2015):e387.

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