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KIZ OpenIR  > 科研部门  > 肿瘤信号转导（陈勇彬）
Increased Levels of beta-catenin, LEF-1, and HPA-1 Correlate with Poor Prognosis for Acral Melanoma with Negative BRAF and NRAS Mutation in BRAF Exons 11 and 15 and NRAS Exons 1 and 2
Xu SX1,2; Yang ZZ*1; Zhang JY1; Jiang YX1; Chen YB3; Li HJ4; Liu XF1; Xu D1; Chen YJ1; Yang YH1; Zhang Y1; Li DX1; Xia JF1; yangzuozhang@163.com
2015
发表期刊DNA AND CELL BIOLOGY
卷号34期号:1页码:69-77
合作性质其它
摘要To determine the expression of beta-catenin, lymphoid enhancer-binding protein-1 (LEF-1), and heparanase-1 (HPA-1) and to evaluate these proteins' potential prognostic values in malignant acral melanoma without mutations in BRAF exons 11 and 15 and NRAS exons 1 and 2, specimens from 90 patients with wild-type BRAF and NRAS were assessed and analyzed by immunohistochemistry and western blotting. The positive expression of beta-catenin, lymphoid enhancer-binding protein-1, and heparanase-1 was observed in 36 (72%), 31 (62%), and 32 (64%) of the detected acral melanomas, respectively. The expression of beta-catenin, lymphoid enhancer-binding protein-1, and heparanase-1 was not correlated with gender, age, or diseased body parts (p>0.05), but was significantly positively correlated with the tumor node metastasis (TNM) stage and metastasis (correlation=0.406 and 0.716, 0.397 and 0.582, 0.353 and 0.579; p=0.040 and 0.0001, 0.0040 and 0.0001, 0.0120 and 0.0001, respectively). We also observed that the increased expression of beta-catenin, lymphoid enhancer-binding protein-1, and heparanase-1 was significantly correlated with decreased survival and poor prognosis (p=0.001, 0.010, and 0.023, respectively). A multifactorial analysis using Cox's regression model revealed that beta-catenin, lymphoid enhancer-binding protein-1, heparanase-1, and the TNM stage were all independent factors in malignant melanoma (risk ratios were 7.294, 5.550, 5.622, and 4.794; p-values were 0.007, 0.018, 0.018, and 0.029, respectively). This study may provide the basis for the use of beta-catenin, lymphoid enhancer-binding protein-1, and heparanase-1 as novel targets in the treatment of malignant invasion and metastasis in acral melanoma cancer. The expression of beta-catenin, LEF-1, and HPA-1 was assessed and compared in malignant melanoma with that of peritumoral tissue and benign nevus in the patients with negative mutations in BRAF exons 11 and 15 and NRAS exons 1 and 2. The study may provide the basis for beta-catenin, LEF-1, and HPA-1 as new targets in the treatment of malignant invasion and metastasis in melanoma cancer.
资助者This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province.
收录类别SCI
语种英语
资助者This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province. ; This research was supported, in part, by grants (no. 81260322/H1606, no. 81372322/H1606 and no. 81460440/ H1606) from the National Natural Science Foundation of China, a grant (no. 2012FB163) from the Natural Science Foundation of Yunnan Province, a grant (no. 2011FB201) from the Joint Special Funds for the Department of Science and Technology of Yunnan Province-Kunming Medical University, and a grant (no. D-201242) from the specialty fund of high- level talents medical personnel training of Yunnan province.
文献类型期刊论文
条目标识符http://ir.kiz.ac.cn/handle/152453/8221
专题科研部门_肿瘤信号转导（陈勇彬）
科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者yangzuozhang@163.com
作者单位1.Department of Orthopedics, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, People’s Republic of Chi
2.Department of Orthopedics, The First People’s Hospital of Dali, Dali, People’s Republic of China
3.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, People’s Republic of China
4.Institute of Medical Biology, Chinese Academy of Medical Science, Kunming, People’s Republic of Chin
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GB/T 7714		 Xu SX,Yang ZZ*,Zhang JY,et al. Increased Levels of beta-catenin, LEF-1, and HPA-1 Correlate with Poor Prognosis for Acral Melanoma with Negative BRAF and NRAS Mutation in BRAF Exons 11 and 15 and NRAS Exons 1 and 2[J]. DNA AND CELL BIOLOGY,2015,34(1):69-77.
APA Xu SX.,Yang ZZ*.,Zhang JY.,Jiang YX.,Chen YB.,...&yangzuozhang@163.com.(2015).Increased Levels of beta-catenin, LEF-1, and HPA-1 Correlate with Poor Prognosis for Acral Melanoma with Negative BRAF and NRAS Mutation in BRAF Exons 11 and 15 and NRAS Exons 1 and 2.DNA AND CELL BIOLOGY,34(1),69-77.
MLA Xu SX,et al."Increased Levels of beta-catenin, LEF-1, and HPA-1 Correlate with Poor Prognosis for Acral Melanoma with Negative BRAF and NRAS Mutation in BRAF Exons 11 and 15 and NRAS Exons 1 and 2".DNA AND CELL BIOLOGY 34.1(2015):69-77.
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