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	Delineation of Early and Later Adult Onset Depression by Diffusion Tensor Imaging
	Cheng YQ1; Xu J2; Yu HJ3; Nie BB4; Li N1; Luo CR3; Li HJ3; Liu F1; Bai Y1; Shan BC4; Xu L*5; Xu XF*1; lxu@vip.163.com; xfxu2004@sina.com
	2014
发表期刊	PLOS ONE
卷号	9期号:11页码:e112307
合作性质	其它
摘要	Background: Due to a lack of evidence, there is no consistent age of onset to define early onset (EO) versus later onset (LO) major depressive disorder (MDD). Fractional anisotropy (FA), derived from diffusion tensor imaging (DTI), has been widely used to study neuropsychiatric disorders by providing information about the brain circuitry, abnormalities of which might facilitate the delineation of EO versus LO MDD. Method: In this study, 61 pairs of untreated, non-elderly, first-episode MDD patients and healthy controls (HCs) aged 18-45 years old received DTI scans. The voxel-based analysis method (VBM), classification analysis, using the Statistical Package for the Social Sciences (SPSS), and regression analyses were used to determine abnormal FA clusters and their correlations with age of onset and clinical symptoms. Results: Classification analysis suggested in the best model that there were two subgroups of MDD patients, delineated by an age of onset of 30 years old, by which MDD patients could be divided into EO (18-29 years old) and LO (30-45 years old) groups. LO MDD was characterized by decreased FA, especially in the white matter (WM) of the fronto-occipital fasciculus and posterior limb of internal capsule, with a negative correlation with the severity of depressive symptoms; in marked contrast, EO MDD showed increased FA, especially in the WM of the corpus callosum, corticospinal midbrain and inferior fronto-occipital fasciculus, while FA of the WM near the midbrain had a positive correlation with the severity of depressive symptoms. Conclusion: Specific abnormalities of the brain circuitry in EO vs. LO MDD were delineated by an age of onset of 30 years old, as demonstrated by distinct abnormal FA clusters with opposite correlations with clinical symptoms. This DTI study supported the evidence of an exact age for the delineation of MDD, which could have broad multidisciplinary importance.
资助者	This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167).
收录类别	SCI
语种	英语
资助者	This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167). ; This work is supported by grants from National Natural Science Foundation of China (81101005, 81160379, 81160171, U1032605, and 81161120536), the 973 Program from the Ministry of Science and Technology of China (2009CB941300), Yunnan Provincial Health Science and Technology Plan (2011WS008), the NSFC-Yunnan Joint Foundation (U1032605), and the united founding of Yunnan Administration of Science & Technology and Kunming Medical University (2011FB167).
WOS记录号	WOS:000347709300051
引用统计	被引频次：27[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/8253
专题	科研部门_学习记忆的分子神经机制（徐林） 科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	lxu@vip.163.com; xfxu2004@sina.com
作者单位	1.Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, PR China 2.Department of Internal Medicine, First Affiliated Hospital of Kunming Medical University, Kunming, PR China 3.Magnetic Resonance Imaging Center, the First Hospital of Kunming City, Kunming, PR China 4.Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, PR Chin 5.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, PR China
推荐引用方式 GB/T 7714	Cheng YQ,Xu J,Yu HJ,et al. Delineation of Early and Later Adult Onset Depression by Diffusion Tensor Imaging[J]. PLOS ONE,2014,9(11):e112307.
APA	Cheng YQ.,Xu J.,Yu HJ.,Nie BB.,Li N.,...&xfxu2004@sina.com.(2014).Delineation of Early and Later Adult Onset Depression by Diffusion Tensor Imaging.PLOS ONE,9(11),e112307.
MLA	Cheng YQ,et al."Delineation of Early and Later Adult Onset Depression by Diffusion Tensor Imaging".PLOS ONE 9.11(2014):e112307.

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2015020608.pdf（553KB）	期刊论文	出版稿	开放获取	CC BY-NC-SA	请求全文

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