Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator

	Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator
	Shi Q 1; Li S 1; Li SX 1,2; Jiang A 1; Chen YB 3,4; Jiang J*1,5; jin.jiang@UTSouthwestern.edu
	2014
发表期刊	PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷号	111 期号:52 页码:E5651-E5660
合作性质	其它
摘要	Hedgehog (Hh) signaling governs many developmental processes by regulating the balance between the repressor (Ci(R)/Gli(R)) and activator (Ci(A)/Gli(A)) forms of Cubitus interruptus (Ci)/gliomaassociated oncogene homolog (Gli) transcription factors. Although much is known about how Ci(R)/Gli(R) is controlled, the regulation of Ci(A)/Gli(A) remains poorly understood. Here we demonstrate that Casein kinase 1 (CK1) sustains Hh signaling downstream of Costal2 and Suppressor of fused (Sufu) by protecting Ci(A) from premature degradation. We show that Hh stimulates Ci phosphorylation by CK1 at multiple Ser/Thr-rich degrons to inhibit its recognition by the Hh-induced MATH and BTB domain containing protein (HIB), a substrate receptor for the Cullin 3 family of E3 ubiquitin ligases. In Hh-receiving cells, reduction of CK1 activity accelerated HIB-mediated degradation of Ci(A), leading to premature loss of pathway activity. We also provide evidence that Gli(A) is regulated by CK1 in a similar fashion and that CK1 acts downstream of Sufu to promote Sonic hedgehog signaling. Taken together, our study not only reveals an unanticipated and conserved mechanism by which phosphorylation of Ci/Gli positively regulates Hh signaling but also provides the first evidence, to our knowledge, that substrate recognition by the Cullin 3 family of E3 ubiquitin ligases is negatively regulated by a kinase.
关键词	Hedgehog Ck1 Ci Gli Spop
资助者	This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.).
收录类别	SCI
语种	英语
资助者	This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.). ; This work was supported by National Institutes of Health Grants GM061269 and GM067045 and Welch Founda- tion Grant I-1603 (to J.J.), and National Science Foundation of China Grants 31328017, 81322030, and 31271579 (to Y.C.).
WOS记录号	WOS:000347444400010
引用统计	被引频次：18[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/8255
专题	科研部门_肿瘤信号转导（陈勇彬）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	jin.jiang@UTSouthwestern.edu
作者单位	1.Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 2.Institute of Biomedical Sciences, East China Normal University, Shanghai 200062, China 3.Key Laboratory of Animal Models and Human Disease Mechanisms,Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 4.Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 5.Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235
推荐引用方式 GB/T 7714	Shi Q,Li S,Li SX,et al. Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2014,111(52):E5651-E5660.
APA	Shi Q.,Li S.,Li SX.,Jiang A.,Chen YB.,...&jin.jiang@UTSouthwestern.edu.(2014).Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,111(52),E5651-E5660.
MLA	Shi Q,et al."Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111.52(2014):E5651-E5660.

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