Effects of Abnormal Early Rearing Environments on Fear Memory in Adult Rats

	Effects of Abnormal Early Rearing Environments on Fear Memory in Adult Rats
其他题名	大鼠成年前异常生活环境对其成年后恐惧记忆的影响
	Li CY 1,3; Zhang B 2; Li ZB 1; Huang FL 1; Tian SW1; Hu XT3; tsw.neuro@126.com ; xthu@mail.kiz.ac.cn
	2009
发表期刊	动物学研究
卷号	30 期号:1 页码:31−37
合作性质	其它
摘要	In the present experiment, Pavlovian fear conditioning was adopted to study the effects of different early rearing environments on fear conditioning in adult rats. Weaned rats were reared in three manipulable environments （enriched, social and isolated conditions）. After 8 weeks, fear conditioning （characterized by percentage of freezing） was observed and analyzed, and rats＇ weight, locomoter activity and foot-shock sensitivity were operated too. The results showed that：（1） Compared with control group, the level of conditioned fear was significantly increased in enriched group, but significantly decreased in isolated group; （2） Enriched and isolated conditions influenced rat＇s weight significantly; （3） Different rearing conditions have no effect on locomoter activity and foot-shock sensitivity. These results indicated that early enriched condition could improve the tone-evoked fear conditioning response, while isolated condition impaired the response.
其他摘要	为了探讨早期饲养环境对成年后大鼠条件化恐惧的影响,实验采用巴氏恐惧条件化的方法对不同饲养环境下的大鼠进行了行为检测。具体操作为:把断奶后的大鼠饲养在3个不同的人工控制的环境中(丰富环境、社群环境和贫瘠环境);8周后进行恐惧条件化训练和测试(指标为僵直百分比),以及检测不同饲养环境下的大鼠的体重、自发活动和足部电击敏感性。结果显示:与社群组相比,丰富组的大鼠条件化僵直水平明显增加,而贫瘠组的明显减少;丰富和贫瘠环境明显的影响了大鼠的体重;不同环境对自发活动和足部电击敏感性没有影响。这些结果说明幼年期的丰富环境能提高成年后大鼠的由声音诱发的条件化恐惧反应,而贫瘠环境则削弱了这种反应。
关键词	Fear Conditioning Freezing Enriched Condition Isolated Condition Locomoter Activity Foot-shock Sensitivity
资助者	National Natural Science Foundation of China(30770689);Scientific Research Fund of Hunan Provincial Education Department (05B045);National Basic Research Program of China (2002CB410803-04). ; National Natural Science Foundation of China(30770689);Scientific Research Fund of Hunan Provincial Education Department (05B045);National Basic Research Program of China (2002CB410803-04). ; National Natural Science Foundation of China(30770689);Scientific Research Fund of Hunan Provincial Education Department (05B045);National Basic Research Program of China (2002CB410803-04). ; National Natural Science Foundation of China(30770689);Scientific Research Fund of Hunan Provincial Education Department (05B045);National Basic Research Program of China (2002CB410803-04).
收录类别	其他
语种	英语
资助者	National Natural Science Foundation of China(30770689);Scientific Research Fund of Hunan Provincial Education Department (05B045);National Basic Research Program of China (2002CB410803-04). ; National Natural Science Foundation of China(30770689);Scientific Research Fund of Hunan Provincial Education Department (05B045);National Basic Research Program of China (2002CB410803-04). ; National Natural Science Foundation of China(30770689);Scientific Research Fund of Hunan Provincial Education Department (05B045);National Basic Research Program of China (2002CB410803-04). ; National Natural Science Foundation of China(30770689);Scientific Research Fund of Hunan Provincial Education Department (05B045);National Basic Research Program of China (2002CB410803-04).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/833
专题	科研部门_神经系统编码（胡新天）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	tsw.neuro@126.com; xthu@mail.kiz.ac.cn
作者单位	1.Department of Physiology, Medical college, Nanhua University, Hengyang Hunan 421001, China 2.Section of Primate Neuroscience Research Laboratory and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming Yunnan 650223, China 3.Laboratory of Sensory-motor Integration Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming Yunnan 650223, China
推荐引用方式 GB/T 7714	Li CY,Zhang B,Li ZB,et al. Effects of Abnormal Early Rearing Environments on Fear Memory in Adult Rats[J]. 动物学研究,2009,30(1):31−37.
APA	Li CY.,Zhang B.,Li ZB.,Huang FL.,Tian SW*.,...&xthu@mail.kiz.ac.cn.(2009).Effects of Abnormal Early Rearing Environments on Fear Memory in Adult Rats.动物学研究,30(1),31−37.
MLA	Li CY,et al."Effects of Abnormal Early Rearing Environments on Fear Memory in Adult Rats".动物学研究 30.1(2009):31−37.

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