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	Impaired contextual fear extinction and hippocampal synaptic plasticity in adult rats induced by prenatal morphine exposure
	Tan JW1,2; Duan TT1,3; Zhou QX1; Ding ZY1,4; Jing L1,2; Cao J1; Wang LP1; Mao RR*1; Xu L*1; talktomaomao@163.com; lxu@vip.163.com
	2015
发表期刊	ADDICTION BIOLOGY
卷号	20期号:4页码:652-662
合作性质	其它
摘要	Prenatal opiate exposure causes a series of neurobehavioral disturbances by affecting brain development. However, the question of whether prenatal opiate exposure increases vulnerability to memory-related neuropsychiatric disorders in adult offspring remains largely unknown. Here, we found that rats prenatally exposed to morphine (PM) showed impaired acquisition but enhanced maintenance of contextual fear memory compared with control animals that were prenatally exposed to saline (PS). The impairment of acquisition was rescued by increasing the intensity of footshocks (1.2mA rather than 0.8mA). Meanwhile, we also found that PM rats exhibited impaired extinction of contextual fear, which is associated with enhanced maintenance of fear memory. The impaired extinction lasted for 1 week following extinction training. Furthermore, PM rats exhibited reduced anxiety-like behavior in the elevated plus-maze and light/dark box test without differences in locomotor activity. These alterations in PM rats were mirrored by abnormalities in synaptic plasticity in the Schaffer collateral-CA1 synapses of the hippocampus in vivo. PS rats showed blocked long-term potentiation and enabled long-term depression in CA1 synapses following contextual fear conditioning, while prenatal morphine exposure restricted synaptic plasticity in CA1 synapses. The smaller long-term potentiation in PM rats was not further blocked by contextual fear conditioning, and the long-term depression enabled by contextual fear conditioning was abolished. Taken together, our results provide the first evidence suggesting that prenatal morphine exposure may increase vulnerability to fear memory-related neuropsychiatric disorders in adulthood.
关键词	Contextual Fear Conditioning Extinction Long-term Depression Long-term Potentiation Prenatal Morphine Exposure
资助者	This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048).
收录类别	SCI
语种	英语
资助者	This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048). ; This work was supported by 973 program from the Ministry of Science and Technology of China (2013CB835103), Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020002), NSFC-CIHR Joint Grant (81161120536), National Natural Science Foundation of China (U1032605, U1132602 and 31100786) and Science and Techno- logy Program of Yunnan Province (2013GA003, 2010CD104 and 2013FA048).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/9172
专题	科研部门_学习记忆的分子神经机制（徐林） 科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	talktomaomao@163.com; lxu@vip.163.com
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Disease, Laboratory of Learning and Memory, Kunming Institute of Zoology, The Chinese Academy of Sciences, China 2.Kunming College of Life Science, University of Chinese Academy of Sciences, China 3.School of Life Sciences, University of Science and Technology of China, China 4.School of Life Sciences, Anhui University, China
推荐引用方式 GB/T 7714	Tan JW,Duan TT,Zhou QX,et al. Impaired contextual fear extinction and hippocampal synaptic plasticity in adult rats induced by prenatal morphine exposure[J]. ADDICTION BIOLOGY,2015,20(4):652-662.
APA	Tan JW.,Duan TT.,Zhou QX.,Ding ZY.,Jing L.,...&lxu@vip.163.com.(2015).Impaired contextual fear extinction and hippocampal synaptic plasticity in adult rats induced by prenatal morphine exposure.ADDICTION BIOLOGY,20(4),652-662.
MLA	Tan JW,et al."Impaired contextual fear extinction and hippocampal synaptic plasticity in adult rats induced by prenatal morphine exposure".ADDICTION BIOLOGY 20.4(2015):652-662.

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