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	A beta-defensin 1-like antimicrobial peptide from the tree shrew, Tupaia belangeri
	Yang XM1; Dong L2; Liu R*1; Lv LB2; Yan XW1; Lai R*1,2; rlai72@njau.edu.cn; liuruisl@163.com
	2012
发表期刊	GENE
卷号	509期号:2页码:258-262
合作性质	其它
摘要	A novel beta-defensin 1-like antimicrobial peptide (beta-defensin 1TB) containing 36 amino acid residues was purified and characterized from the serum of the tree shrew, Tupaia belangeri. Its amino acid sequence was determined as DHYLCVKNEGICLYSSCPSYTKIEGTCYGGKAKCCK, by Edman degradation, mass spectrometry analysis, and cDNA cloning. Evolution analysis indicated that beta-defensin 1TB showed maximal similarity to the beta-defensin 1 identified from cotton-top tamarin, Saguinus oedipus. beta-defensin 1TB exerted potential antimicrobial activities against wide spectrum of microorganisms including Gram-negative and -positive bacteria and fungi. It showed little hemolitic activity to human or rabbit red cells. To the best of our knowledge, this is the first report of antimicrobial peptide from Tupaiidae.
关键词	Defensin Tupaia Belangeri Antimicrobial Activity Hemolitic Activity
资助者	This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences.
收录类别	SCI
语种	英语
资助者	This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences. ; This work was supported by the Chinese Academy of Sciences (KSCX2-EW-R-11 and KSCX2-EW-J-23), the Ministry of Science and Technology(2010CB529800),andtheKeyLaboratoryofAnimalModels and Human Disease Mechanisms, Chinese Academy of Sciences.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/9261
专题	科研部门_天然药物功能蛋白质学科组（赖仞） 科研部门_动物模型与人类重大疾病机理重点实验室 中国科学院昆明灵长类研究中心
通讯作者	rlai72@njau.edu.cn; liuruisl@163.com
作者单位	1.Life Sciences College of Nanjing Agricultural University, Nanjing 210095, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
推荐引用方式 GB/T 7714	Yang XM,Dong L,Liu R*,et al. A beta-defensin 1-like antimicrobial peptide from the tree shrew, Tupaia belangeri[J]. GENE,2012,509(2):258-262.
APA	Yang XM.,Dong L.,Liu R*.,Lv LB.,Yan XW.,...&liuruisl@163.com.(2012).A beta-defensin 1-like antimicrobial peptide from the tree shrew, Tupaia belangeri.GENE,509(2),258-262.
MLA	Yang XM,et al."A beta-defensin 1-like antimicrobial peptide from the tree shrew, Tupaia belangeri".GENE 509.2(2012):258-262.

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