| Delta EEG Activity in Left Orbitofrontal Cortex in Rats Related to Food Reward and Craving | |
| 其他题名 | 食物奖赏和渴求行为相关的大鼠左侧眶额叶皮质Delta频段脑电活动 |
| Fu Y1,2; Chen YM1,2; Zeng T1; Peng YP1; Tian SH1; Ma YY*1,3; yuanma0716@vip.sina.com | |
| 2008 | |
| 发表期刊 | 动物学研究
 |
| 卷号 | 29期号:3页码:260-264 |
| 合作性质 | 其它 |
| 其他摘要 | 眶额叶皮质与中脑边缘多巴胺奖赏系统有着复杂的相互纤维联系.先前的研究探讨了药物成瘾过程中眶额叶皮质的脑电活动.在本实验中,将探讨食物奖赏和渴求过程中该皮质的脑电活动.实验采用了两个环境:对照环境和食物刺激相关的环境.首先,训练大鼠在食物刺激相关的环境中吃巧克力花生豆,而后在该环境中设置两种不同的刺激方式:能看到和闻到但不能吃到(渴求实验),或者仍旧可以吃到巧克力花生豆(奖赏实验):同时进行左侧眶额叶皮质的脑电记录.结果发现,在食物刺激相关的环境中大鼠Delta频段(2-4Hz)的脑电活动与食物刺激显著相关,此外,与在对照环境中相比,其相对功率在食物渴求时下降而在食物奖赏时升高.本实验表明,食物相关的奖励可以改变大鼠眶额叶皮质的脑电活动,而且,Delta频段的脑电活动能够作为监测该奖励的一个指标.; The orbitofrontal cortex （OFC） is particularly important for the neural representation of reward value. Previous studies indicated that electroencephalogram （EEG） activity in the OFC was involved in drug administration and withdrawal. The present study investigated EEG activity in the OFC in rats during the development of food reward and craving. Two environments were used separately for control and food-related EEG recordings. In the food-related environment rats were first trained to eat chocolate peanuts; then they either had no access to this food, but could see and smell it （craving trials）, or had free access to this food （reward trials）. The EEG in the left OFC was recorded during these trials. We showed that, in the food-related environment the EEG activity peaking in the delta band （2-4 Hz） was significantly correlated with the stimulus, increasing during food reward and decreasing during food craving when compared with that in the control environment. Our data suggests that EEG activity in the OFC can be altered by food reward; moreover, delta rhythm in this region could be used as an index monitoring changed signal underlying this reward. |
| 关键词 | Orbitofrontal Cortex Eeg Reward Craving Delta Band |
| 资助者 | National Science Foundation of China （30470553;30530270;30670669; 30770700）; 973 Program （2005CB522803; 2007CB947703）; 863 Program （07013810; 2006AA02AII6）; The Major State Basic Research of China （2003CB716600）; Chinese-Finnish International Collaboration Project-neuro （30621130076）; Program of CASC （KSCXI-YW-R-33;YZ200737）; National Key Technologies R ＆ D Program and Yunnan Science and Technique Program （2006PT08-2） ; National Science Foundation of China （30470553;30530270;30670669; 30770700）; 973 Program （2005CB522803; 2007CB947703）; 863 Program （07013810; 2006AA02AII6）; The Major State Basic Research of China （2003CB716600）; Chinese-Finnish International Collaboration Project-neuro （30621130076）; Program of CASC （KSCXI-YW-R-33;YZ200737）; National Key Technologies R ＆ D Program and Yunnan Science and Technique Program （2006PT08-2） ; National Science Foundation of China （30470553;30530270;30670669; 30770700）; 973 Program （2005CB522803; 2007CB947703）; 863 Program （07013810; 2006AA02AII6）; The Major State Basic Research of China （2003CB716600）; Chinese-Finnish International Collaboration Project-neuro （30621130076）; Program of CASC （KSCXI-YW-R-33;YZ200737）; National Key Technologies R ＆ D Program and Yunnan Science and Technique Program （2006PT08-2） ; National Science Foundation of China （30470553;30530270;30670669; 30770700）; 973 Program （2005CB522803; 2007CB947703）; 863 Program （07013810; 2006AA02AII6）; The Major State Basic Research of China （2003CB716600）; Chinese-Finnish International Collaboration Project-neuro （30621130076）; Program of CASC （KSCXI-YW-R-33;YZ200737）; National Key Technologies R ＆ D Program and Yunnan Science and Technique Program （2006PT08-2） |
| 收录类别 | 其他 |
| 语种 | 英语 |
| 资助者 | National Science Foundation of China （30470553;30530270;30670669; 30770700）; 973 Program （2005CB522803; 2007CB947703）; 863 Program （07013810; 2006AA02AII6）; The Major State Basic Research of China （2003CB716600）; Chinese-Finnish International Collaboration Project-neuro （30621130076）; Program of CASC （KSCXI-YW-R-33;YZ200737）; National Key Technologies R ＆ D Program and Yunnan Science and Technique Program （2006PT08-2） ; National Science Foundation of China （30470553;30530270;30670669; 30770700）; 973 Program （2005CB522803; 2007CB947703）; 863 Program （07013810; 2006AA02AII6）; The Major State Basic Research of China （2003CB716600）; Chinese-Finnish International Collaboration Project-neuro （30621130076）; Program of CASC （KSCXI-YW-R-33;YZ200737）; National Key Technologies R ＆ D Program and Yunnan Science and Technique Program （2006PT08-2） ; National Science Foundation of China （30470553;30530270;30670669; 30770700）; 973 Program （2005CB522803; 2007CB947703）; 863 Program （07013810; 2006AA02AII6）; The Major State Basic Research of China （2003CB716600）; Chinese-Finnish International Collaboration Project-neuro （30621130076）; Program of CASC （KSCXI-YW-R-33;YZ200737）; National Key Technologies R ＆ D Program and Yunnan Science and Technique Program （2006PT08-2） ; National Science Foundation of China （30470553;30530270;30670669; 30770700）; 973 Program （2005CB522803; 2007CB947703）; 863 Program （07013810; 2006AA02AII6）; The Major State Basic Research of China （2003CB716600）; Chinese-Finnish International Collaboration Project-neuro （30621130076）; Program of CASC （KSCXI-YW-R-33;YZ200737）; National Key Technologies R ＆ D Program and Yunnan Science and Technique Program （2006PT08-2） |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/931 |
| 专题 | 认知障碍病理学 科研部门_动物模型与人类重大疾病机理重点实验室 中国科学院昆明灵长类研究中心 |
| 通讯作者 | yuanma0716@vip.sina.com |
| 作者单位 | 1.Laboratory of Primate Neuroscience Research and Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming Yunnan 650223, China 2.Graduate University of the Chinese Academy of Sciences, Beijing 100049, China 3.Kunming Primate Research Center, the Chinese Academy of Sciences, Kunming Yunnan 650223, China |
| 推荐引用方式 GB/T 7714 | Fu Y,Chen YM,Zeng T,et al. Delta EEG Activity in Left Orbitofrontal Cortex in Rats Related to Food Reward and Craving[J]. 动物学研究,2008,29(3):260-264. |
| APA | Fu Y.,Chen YM.,Zeng T.,Peng YP.,Tian SH.,...&yuanma0716@vip.sina.com.(2008).Delta EEG Activity in Left Orbitofrontal Cortex in Rats Related to Food Reward and Craving.动物学研究,29(3),260-264. |
| MLA | Fu Y,et al."Delta EEG Activity in Left Orbitofrontal Cortex in Rats Related to Food Reward and Craving".动物学研究 29.3(2008):260-264. |
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| 2017031822.pdf（154KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 请求全文 | |
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