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KIZ OpenIR  > 科研部门  > 肿瘤生物学（陈策实）
The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27(Kip1)
Wang CY1,2,3; Nie Z3; Zhou ZM1; Zhang HL1; Liu R1; Wu J1,2,4; Qin JY1,2; Ma Y3; Chen L3; Li SM3; Chen WL5; Li FB1,2,3; Shi PG1,2; Wu YY3; Shen J3; Chen CS*1; chenc@mail.kiz.ac.cn
2015
发表期刊ONCOTARGET
卷号6期号:19页码:17685-17697
合作性质其它
摘要

Growing evidence suggests that YAP/TAZ are mediators of the Hippo pathway and promote breast cancer. However, the roles of YAP/TAZ transcription factor partners TEADs in breast cancer remain unclear. Here we found that TEAD4 was expressed in breast cancer cell lines, especially in triple negative breast cancers (TNBC) cell lines. TEAD4 binds to KLF5. Knockdown of either TEAD4 or KLF5 in HCC1937 and HCC1806 cells induced the expression of CDK inhibitor p27. Depletion of either TEAD4 or KLF5 activated the p27 gene promoter and increased the p27 mRNA levels. Depletion of p27 partially prevents growth inhibition caused by TEAD4 and KLF5 knockdown. TEAD4 overexpression stimulated proliferation in vitro and tumor growth in mice, while stable knockdown of TEAD4 inhibited proliferation in vitro and tumor growth in mice. Thus TEAD4 and KLF5, in collaboration, promoted TNBC cell proliferation and tumor growth in part by inhibiting p27 gene transcription. TEAD4 is a potential target and biomarker for the development of novel therapeutics for breast cancer.

关键词Tead4 Klf5 P27 Hippo Pathway Tnbc
资助者This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022).
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资助者This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022). ; This study was supported by Strategic Priority Research Program of the Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Research (XDA01040406), National Nature Science Foundation of China (81460401, 81325016, U1132605 and 81120108019) and Department of Science and Technology of Yunnan Province-Kunming Medical University (4FB022).
文献类型期刊论文
条目标识符http://ir.kiz.ac.cn/handle/152453/9324
专题科研部门_肿瘤生物学（陈策实）
科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者chenc@mail.kiz.ac.cn
作者单位1.Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China
2.University of The Chinese Academy of Sciences, Beijing, China
3.First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
4.Department of Biochemistry, Kunming Medical University, Kunming, Yunnan, China
5.Cancer Hospital, Kunming Medical University, Kunming, Yunnan, China
推荐引用方式
GB/T 7714		 Wang CY,Nie Z,Zhou ZM,et al. The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27(Kip1)[J]. ONCOTARGET,2015,6(19):17685-17697.
APA Wang CY.,Nie Z.,Zhou ZM.,Zhang HL.,Liu R.,...&chenc@mail.kiz.ac.cn.(2015).The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27(Kip1).ONCOTARGET,6(19),17685-17697.
MLA Wang CY,et al."The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27(Kip1)".ONCOTARGET 6.19(2015):17685-17697.
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