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KIZ OpenIR  > 结构生物信息学
Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study
Li WX1,2; Lv WW3; Dai SX2; Pan M3; Huang JF*2,4,5; huangjf@mail.kiz.ac.cn
2015
发表期刊LIPIDS IN HEALTH AND DISEASE
卷号14期号:X页码:e101
合作性质其它
摘要

Background

Dyslipidemia is a well-established risk factor for cardiovascular disease. Serum lipids were affected by several gene polymorphisms, folate, homocysteine and other metabolite levels. We aim to investigate the effects of homocysteine metabolism enzyme polymorphisms (MTHTR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) and their interactions with folate, homocysteine on serum lipid levels in Chinese patients with hypertension.

Methods

Participants were 480 hypertensive adults that enrolled in September to December 2005 from six different Chinese hospitals (Harbin, Shanghai, Shenyang, Beijing, Xi’an, and Nanjing). Known MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G genotypes were determined by PCR-RFLP methods. Serum folate was measured by chemiluminescent immunoassay, homocysteine was measured by high-performance liquid chromatography, serum lipids parameters were determined by an automatic biochemistry analyzer, low-density lipoprotein was calculated by Friedewald’s equation. Unitary linear regression model was used to assess the associations of gene polymorphisms, folate and homocysteine on serum lipid profiles. Unconditional logistic regression model was applied to test the interactions of folate, homocysteine and gene polymorphisms on dyslipidemia.


Results

No correlations between gene polymorphisms and homocysteine on serum lipid profiles. Compared with normal folate patients, patients with low folate showed higher odds of hypertriglyceridemia (OR = 2.02, 95 % CI: 1.25-3.25, P = 0.004) and low levels of high-density lipoprotein cholesterol (OR = 1.88, 95 % CI: 1.07-3.28, P = 0.027). Each of four gene polymorphisms (MTHTR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) combined with low folate showed higher odds of hypertriglyceridemia (P for trend: 0.049, 0.004, 0.007 and 0.005, respectively). MTHFR C677T and A1298C with low folate showed higher odds of low levels of high-density lipoprotein cholesterol (P for trend: 0.008 and 0.031).

Conclusions

Low folate status and homocysteine metabolism gene polymorphisms (MTHTR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) may have a synergistic effect increased the incidence of dyslipidemia in Chinese hypertensive population.

关键词Mthfr C677t Mthfr A1298c Mtr A2756g Mtrr A66g Folate Homocysteine Serum Lipids
资助者This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis.
收录类别SCI
语种英语
资助者This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis. ; This work was supported by the National Basic Research Program of China (Grant No. 2013CB835100), and the National Natural Science Foundation of China (Grant No. 31123005 to J.F.H and No. 31401142 to S.X.D). We gratefully thank Shanqun Jiang, Ph.D. (School of Life Sciences, Anhui University, Hefei, China; and Institute of Biomedicine, Anhui Medical University, Hefei, China) and Xiping Xu, M.D., Ph.D. (Institute of Biomedicine, Anhui Medical University, Hefei, China) for providing clinical trial data and helpful advice on the data analysis.
文献类型期刊论文
条目标识符http://ir.kiz.ac.cn/handle/152453/9348
专题结构生物信息学
遗传资源与进化国家重点实验室
通讯作者huangjf@mail.kiz.ac.cn
作者单位1.Institute of Health Sciences, Anhui University, Hefei 230601, PR China
2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, PR China
3.School of Life Sciences, Anhui University, Hefei 230601, PR China
4.KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, PR China
5.Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan, Kunming 650223, PR China
推荐引用方式
GB/T 7714		 Li WX,Lv WW,Dai SX,et al. Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study[J]. LIPIDS IN HEALTH AND DISEASE,2015,14(X):e101.
APA Li WX,Lv WW,Dai SX,Pan M,Huang JF*,&huangjf@mail.kiz.ac.cn.(2015).Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study.LIPIDS IN HEALTH AND DISEASE,14(X),e101.
MLA Li WX,et al."Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study".LIPIDS IN HEALTH AND DISEASE 14.X(2015):e101.
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