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	LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in experimental autoimmune encephalomyelitis mice
	Sun JJ1; Ren QG*1; Xu L2,3; Zhang ZJ*1; renqingguo1976@163.com; zhijunzhang@seu.edu.cn
	2015
发表期刊	SCIENTIFIC REPORTS
卷号	5期号:X页码:e14235
合作性质	其它
摘要	More than 50% of multiple sclerosis patients develop cognitive impairment. However, the underlying mechanisms are still unclear, and there is no effective treatment. LINGO-1 (LRR and Ig domain containing NOGO receptor interacting protein 1) has been identified as an inhibitor of oligodendrocyte differentiation and myelination. Using the experimental autoimmune encephalomyelitis (EAE) mouse model, we assessed cognitive function at early and late stages of EAE, determined brain expression of myelin basic protein (MBP) and investigated whether the LINGO-1 antibody could restore deficits in learning and memory and ameliorate any loss of MBP. We found that deficits in learning and memory occurred in late EAE and identified decreased expression of MBP in the parahippocampal cortex (PHC) and fimbria-fornix. Moreover, the LINGO-1 antibody significantly improved learning and memory in EAE and partially restored MBP in PHC. Furthermore, the LINGO-1 antibody activated the AKT/mTOR signaling pathway regulating myelin growth. Our results suggest that demyelination in the PHC and fimbria-fornix might contribute to cognitive deficits and the LINGO-1 antibody could ameliorate these deficits by promoting myelin growth in the PHC. Our research demonstrates that LINGO-1 antagonism may be an effective approach to the treatment of the cognitive impairment of multiple sclerosis patients.
资助者	This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002).
收录类别	SCI
语种	英语
资助者	This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002). ; This work was supported in part by grants from the National Natural Science Foundation of China (91232707), Grants from National Basic Research Program of China (2013CB835103), Strategic Priority Research Program of Chinese Academy of Science (XDB02020002).
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/9428
专题	科研部门_学习记忆的分子神经机制（徐林） 科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	renqingguo1976@163.com; zhijunzhang@seu.edu.cn
作者单位	1.Department of Neuropsychiatry, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu, China 2.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences &Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, China 3.Graduate School of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式 GB/T 7714	Sun JJ,Ren QG*,Xu L,et al. LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in experimental autoimmune encephalomyelitis mice[J]. SCIENTIFIC REPORTS,2015,5(X):e14235.
APA	Sun JJ,Ren QG*,Xu L,Zhang ZJ*,renqingguo1976@163.com,&zhijunzhang@seu.edu.cn.(2015).LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in experimental autoimmune encephalomyelitis mice.SCIENTIFIC REPORTS,5(X),e14235.
MLA	Sun JJ,et al."LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in experimental autoimmune encephalomyelitis mice".SCIENTIFIC REPORTS 5.X(2015):e14235.

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