A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1

	A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1
	Yang SL 1,2; Yang F 3; Wei NN 4; Hong J 5; Li BW 1,2; Luo L 1,2; Rong MQ 1; Yarov-Yarovoy V 3; Zheng J3; Wang KW4,6,7; Lai R*1; jzheng@ucdavis.edu ; wangkw@qdu.edu.cn ; rlai@mail.kiz.ac.cn
	2015
发表期刊	NATURE COMMUNICATIONS
卷号	6 期号:X 页码:e8297
合作性质	其它
摘要	The capsaicin receptor TRPV1 ion channel is a polymodal nociceptor that responds to heat with exquisite sensitivity through an unknown mechanism. Here we report the identification of a novel toxin, RhTx, from the venom of the Chinese red-headed centipede that potently activates TRPV1 to produce excruciating pain. RhTx is a 27-amino-acid small peptide that forms a compact polarized molecule with very rapid binding kinetics and high affinity for TRPV1. We show that RhTx targets the channel's heat activation machinery to cause powerful heat activation at body temperature. The RhTx-TRPV1 interaction is mediated by the toxin's highly charged C terminus, which associates tightly to the charge-rich outer pore region of the channel where it can directly interact with the pore helix and turret. These findings demonstrate that RhTx binding to the outer pore can induce TRPV1 heat activation, therefore providing crucial new structural information on the heat activation machinery.
资助者	This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y.
收录类别	SCI
语种	英语
资助者	This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y. ; This work was supported by funding from Ministry of Science and Technology of China (2013CB911300 and 2010CB529800), National Science Foundation of China (31025025, 31025025, U1132601 and 31200590), Chinese Academy of Sciences (KSZD-EW-Z-007) and Yunnan Province (2011CI139, 2012BC009) to R.L., Ministry of Science and Technology of China (2013CB531302), National Science Foundation of China (31370741), Ministry of Education of China, the 111 Project (B07001) to K.W.W., National Institutes of Health (R01NS072377) to J.Z. and American Heart Association (14POST19820027) to F.Y.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/9431
专题	科研部门_天然药物功能蛋白质学科组（赖仞）科研部门_动物模型与人类重大疾病机理重点实验室
通讯作者	jzheng@ucdavis.edu; wangkw@qdu.edu.cn; rlai@mail.kiz.ac.cn
作者单位	1.Key Laboratory of Animal Models and Human Disease Mechanisms, Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming 650223, Yunnan, China. 2.University of Chinese Academy of Sciences, Beijing 100009, China 3.Department of Physiology and Membrane Biology, University of California, Davis, California 95616, USA 4.Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, Beijing 100191, China 5.College of Biological Science and Engineering, Fuzhou University, Fuzhou 350116, China 6.Department of Molecular and Cellular Pharmacology, PKU-IDG/McGovern Institute for Brain Research, Peking University School of Pharmaceutical Sciences, Beijing 100191, China 7.Department of Pharmacology, Qingdao University, Qingdao 266021, China
推荐引用方式 GB/T 7714	Yang SL,Yang F,Wei NN,et al. A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1[J]. NATURE COMMUNICATIONS,2015,6(X):e8297.
APA	Yang SL.,Yang F.,Wei NN.,Hong J.,Li BW.,...&rlai@mail.kiz.ac.cn.(2015).A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1.NATURE COMMUNICATIONS,6(X),e8297.
MLA	Yang SL,et al."A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1".NATURE COMMUNICATIONS 6.X(2015):e8297.

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