| Light exposure before learning improves memory consolidation at night | |
| Shan LL1,2,3,4; Guo H1,3,4; Huang JF2,8; Ding YQ5; Richter-Levine G9; Zhou QX*1,2,3; Xu L*1,2,3,4,7; Song NN5; Jia ZP6; Hu XT1,7; qixin_zhou@126.com; lxu@vip.163.com | |
| 2015 | |
| 发表期刊 | SCIENTIFIC REPORTS
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| 卷号 | 5期号:X页码:e15578 |
| 摘要 | Light is recently recognized as a modulator able to activate the hippocampus and modulate memory processing, but little is known about the molecular mechanisms. Here, we report that in mice, a short pulse of white light before learning dramatically improves consolidation of contextual fear memory during the night. The light exposure increases hippocampal active p21-activated kinase 1 (PAK1) and CA1 long-term potentiation (LTP). These light effects are abolished in PAK1 knockout and dominant-negative transgenic mice, but preserved by expression of constitutively active PAK1 in the hippocampus. Our results indicate that light can act as a switch of PAK1 activity that modulate CA1 LTP and thereby memory consolidation without affecting learning and short-term memory. |
| 资助者 | This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助者 | This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. ; This work was supported by 973 Program of the Ministry of Science and Technology of China (2013CB835100 and 2015CB553502 to L.X.), Strategic Priority Research Program of the Chinese Academy of Sciences (XD2020002 to L.X.), National Science Foundation of China (31100775 and 31371141to Q-X.Z.) and Science and Technology Program of Yunnan Province (2013GA003 to L.X.). We thank Wei Xie and Zikai Zhou for providing PAK1 KO mice. We thank Yonggang Yao for some unincluded in vitro studies. |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.kiz.ac.cn/handle/152453/9463 |
| 专题 | 结构生物信息学 科研部门_动物模型与人类重大疾病机理重点实验室 遗传资源与进化国家重点实验室 科研部门_神经系统编码（胡新天） 科研部门_学习记忆的分子神经机制（徐林） |
| 通讯作者 | qixin_zhou@126.com; lxu@vip.163.com |
| 作者单位 | 1.Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Science, Kunming 650223, China 2.KIZ-SU Joint Laboratory of Animal Models and Drug Development, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China 3.Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese Academy of Science, Kunming 650223, China 4.University of the Chinese Academy of Sciences, Beijing 100049, China 5.Collaborative Innovation Center for Brain Science, Department of Anatomy and Neurobiology, Tongji University School of Medicine, 1239 Siping Road, Shanghai 200092, China. 6.Neurosciences &Mental Health, The Hospital for Sick Children, Department of Physiology, Faculty of Medicine, University of Toronto, 555 University Ave., Toronto, Ontario 5MS 3H2, Canada 7.CAS Center for Excellence in Brain Science, 320 Yue Yang Road, Shanghai, 200031, China. 8.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China 9.The Institute for the Study of Affective Neuroscience, and Sagol Department of Neurobiology and Department of Psychology, University of Haifa, Haifa, Israel |
| 推荐引用方式 GB/T 7714 | Shan LL,Guo H,Huang JF,et al. Light exposure before learning improves memory consolidation at night[J]. SCIENTIFIC REPORTS,2015,5(X):e15578. |
| APA | Shan LL.,Guo H.,Huang JF.,Ding YQ.,Richter-Levine G.,...&lxu@vip.163.com.(2015).Light exposure before learning improves memory consolidation at night.SCIENTIFIC REPORTS,5(X),e15578. |
| MLA | Shan LL,et al."Light exposure before learning improves memory consolidation at night".SCIENTIFIC REPORTS 5.X(2015):e15578. |
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