Hantaviruses in Small Mammals and Humans in the Coastal Region of Zhejiang Province, China

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	Hantaviruses in Small Mammals and Humans in the Coastal Region of Zhejiang Province, China
	Zhang YZ*1,2; Lin XD 2,3; Guo WP 2; Fan FN 4; Huang XM 6; Li MH 6; Li MF 3; Chen Y 3; Shi NF 4; Chen XP 3; Wang SB 1; Fu ZF 7; Plyusnin A 8; Wang W 2; Liao XW 5; yongzhenzhang@sohu.com
	2010
发表期刊	JOURNAL OF MEDICAL VIROLOGY
卷号	82 期号:6 页码:987-995
合作性质	其它
摘要	To gain more insights into the epidemiology of hantaviruses in the coastal region of Zhejiang Province, China, the morbidity and mortality of hemorrhagic fever with renal syndrome (HFRS) were analyzed in two coastal areas. Cixi (hilly terrain) and Wenzhou (mountainous terrain). More HFRS cases have been reported in Cixi than in Wenzhou. Annual incidence rate of HERS in Cixi had been on the level of approximately 1 5/100,000 from 1968 (when the first HFRS case was reported) to 2007, with the highest incidence rate of 8.54/100,000 in 1999. The annual incidence rate in Wenzhou has been relatively low, less than 0 5/100,000 since the first HFRS case was reported in 1981. A total of 461 rodents and 199 shrews were captured in these two areas. Hantavirus antibodies were detected in 16 of 241 (6.64%) Rattus norvegicus and 13 of 122(10.66%) R. flavipectus Interestingly, hantavirus antigens were identified in 6 of 196 (3.06%) Suncus murinus. Genetic analysis showed that partial M and S segment sequences recovered from rats in the two regions belong to Seoul virus (SEOV) and can be assigned into two genetic lineages. SEOV variants that belong to these two lineages of viruses are distributed widely in China and have been found outside China. As most trapped rodents were rats and SEOV was the only hantavirus detected, these results suggested that SEOV plays an important role in human hantavirus infections They also reinforce the need for vigilance in preventing HFRS caused by hantaviruses in the coastal region J. Med. Virol. 82:987 995, 2010. (C) 2010 Wiley-Liss, Inc
关键词	Hemorrhagic Fever With Renal Syndrome Hantavirus Seoul Virus
资助者	Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd.
收录类别	SCI
语种	英语
资助者	Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd. ; Grant sponsor: Chinese Ministry of Science and Technology; Grant numbers: 2002DIB40095, 2003BA712A08-02; Grant spon- sor: Zhejiang Tianyuan Bio-Pharmaceutical Co., Ltd.
文献类型	期刊论文
条目标识符	http://ir.kiz.ac.cn/handle/152453/9611
专题	其他
通讯作者	yongzhenzhang@sohu.com
作者单位	1.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China 2.State Key Laboratory for Infectious Disease Prevention and Control, Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China 3.Wenzhou Center for Disease Control and Prevention, Wenzhou, Zhejiang Province, Chin 4.Cixi Center for Disease Control and Prevention, Cixi, Zhejiang Province, China 5.Ruian Center for Disease Control and Prevention, Ruian, Zhejiang Province, China 6.Ohai District Center for Disease Control and Prevention, Ouhai District, Wenzhou, Zhejiang Province, China 7.Department of Pathology, University of Georgia, Athens, Georgia 8.Department of Virology, Infection Biology Research Program, Haartman Institute, University of Helsinki, Helsinki, Finland
推荐引用方式 GB/T 7714	Zhang YZ*,Lin XD,Guo WP,et al. Hantaviruses in Small Mammals and Humans in the Coastal Region of Zhejiang Province, China[J]. JOURNAL OF MEDICAL VIROLOGY,2010,82(6):987-995.
APA	Zhang YZ*.,Lin XD.,Guo WP.,Fan FN.,Huang XM.,...&yongzhenzhang@sohu.com.(2010).Hantaviruses in Small Mammals and Humans in the Coastal Region of Zhejiang Province, China.JOURNAL OF MEDICAL VIROLOGY,82(6),987-995.
MLA	Zhang YZ*,et al."Hantaviruses in Small Mammals and Humans in the Coastal Region of Zhejiang Province, China".JOURNAL OF MEDICAL VIROLOGY 82.6(2010):987-995.

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